TY - JOUR
T1 - Islet encapsulation
T2 - Strategies to enhance islet cell functions
AU - Beck, Jonathan
AU - Angus, Ryan
AU - Madsen, Ben
AU - Britt, David
AU - Vernon, Brent
AU - Nguyen, Kytai T.
PY - 2007/3
Y1 - 2007/3
N2 - Diabetes is one of the most prevalent, costly, and debilitating diseases in the world. Although traditional insulin therapy has alleviated the short-term effects, long-term complications are ubiquitous and harmful. For these reasons, alternative treatment options are being developed. This review investigates one appealing area: cell replacement using encapsulated islets. Encapsulation materials, encapsulation methods, and cell sources are presented and discussed. In addition, the major factors that currently limit cell viability and functionality are reviewed, and strategies to overcome these limitations are examined. This review is designed to introduce the reader to cell replacement therapy and cell and tissue encapsulation, especially as it applies to diabetes.
AB - Diabetes is one of the most prevalent, costly, and debilitating diseases in the world. Although traditional insulin therapy has alleviated the short-term effects, long-term complications are ubiquitous and harmful. For these reasons, alternative treatment options are being developed. This review investigates one appealing area: cell replacement using encapsulated islets. Encapsulation materials, encapsulation methods, and cell sources are presented and discussed. In addition, the major factors that currently limit cell viability and functionality are reviewed, and strategies to overcome these limitations are examined. This review is designed to introduce the reader to cell replacement therapy and cell and tissue encapsulation, especially as it applies to diabetes.
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U2 - 10.1089/ten.2006.0183
DO - 10.1089/ten.2006.0183
M3 - Review article
C2 - 17518605
AN - SCOPUS:34147193338
SN - 1076-3279
VL - 13
SP - 589
EP - 599
JO - Tissue Engineering
JF - Tissue Engineering
IS - 3
ER -