Abstract
Although levodopa and dopaminergic drugs remain the mainstay of therapy for the motor symptoms of Parkinson disease (PD), they fail to address many of the non-motor symptoms of PD including orthostatic hypotension, freezing of gait (FOG) and difficulty with balance, drug-induced paranoia and hallucinations, and drug-induced dyskinesias. Droxidopa, a drug that increases norepinephrine, treats orthostatic hypotension, cholinomimetic drugs sometimes help with FOG and difficulty with balance, pimavanserin, a drug that blocks serotonin receptors, treats paranoia and hallucinations, and anti-glutaminergic drugs treat dyskinesias. Thus, there are ample opportunities for non-dopaminergic drugs in PD.
Original language | English (US) |
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Pages (from-to) | 347-348 |
Number of pages | 2 |
Journal | Journal of Neural Transmission |
Volume | 120 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2013 |
Externally published | Yes |
Keywords
- Levodopa
- Non-dopaminergic drugs
- Non-motor symptoms
- Parkinson disease
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry