Is there a role for gastric accommodation and satiety in asymptomatic obese people?

Doe Young Kim, Michael Camilleri, Joseph A. Murray, Debra A. Stephens, James A. Levine, Duane D. Burton

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Objective: The relationships of gastric accommodation and satiety in moderately obese individuals are unclear. We hypothesized that obese people had increased gastric accommodation and reduced postprandial satiety. The objective of this study was to compare gastric accommodation and satiety between obese and non-obese asymptomatic subjects. Research Methods and Procedures: In 13 obese (body mass index [BMI] ≥ 30 kg/m2; mean BMI, 37.0 ± 4.9 kg/m2) and 19 non-obese control subjects (BMI < 30 kg/ m2; mean BMI, 26.2 ± 2.9 kg/m2), we used single photon emission computed tomography to measure fasting and postprandial gastric volumes and expressed the accommodation response as the ratio of postprandial/fasting volumes. The satiety test measured maximum tolerable volume of ingestion of liquid nutrient meal (Ensure) and symptoms 30 minutes after cessation of ingestion. Results: Total fasting and postprandial gastric volumes and the ratio of postprandial/fasting gastric volume were not different between asymptomatic obese and control subjects. However, the fasting volume of the distal stomach was greater in obese than in control subjects. Maximum tolerable volume of ingested Ensure and aggregate symptom score 30 minutes later were also not different between obese and control subjects. Discussion: Asymptomatic obese individuals (within the BMI range of 32.6 to 48 kg/m2) did not show either increased postprandial gastric accommodation or reduced satiety. These data suggest that gastric accommodation is unlikely to provide an important contribution to development of moderate obesity.

Original languageEnglish (US)
Pages (from-to)655-661
Number of pages7
JournalObesity Research
Volume9
Issue number11
StatePublished - Nov 2001
Externally publishedYes

Fingerprint

satiety
Stomach
stomach
fasting
body mass index
Fasting
Body Mass Index
signs and symptoms (animals and humans)
Eating
ingestion
research methods
meals (menu)
Single-Photon Emission-Computed Tomography
computed tomography
Meals
obesity
Obesity
Food
liquids
nutrients

Keywords

  • Accommodation
  • Gastric volume
  • Satiety

ASJC Scopus subject areas

  • Food Science
  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Public Health, Environmental and Occupational Health

Cite this

Kim, D. Y., Camilleri, M., Murray, J. A., Stephens, D. A., Levine, J. A., & Burton, D. D. (2001). Is there a role for gastric accommodation and satiety in asymptomatic obese people? Obesity Research, 9(11), 655-661.

Is there a role for gastric accommodation and satiety in asymptomatic obese people? / Kim, Doe Young; Camilleri, Michael; Murray, Joseph A.; Stephens, Debra A.; Levine, James A.; Burton, Duane D.

In: Obesity Research, Vol. 9, No. 11, 11.2001, p. 655-661.

Research output: Contribution to journalArticle

Kim, DY, Camilleri, M, Murray, JA, Stephens, DA, Levine, JA & Burton, DD 2001, 'Is there a role for gastric accommodation and satiety in asymptomatic obese people?', Obesity Research, vol. 9, no. 11, pp. 655-661.
Kim DY, Camilleri M, Murray JA, Stephens DA, Levine JA, Burton DD. Is there a role for gastric accommodation and satiety in asymptomatic obese people? Obesity Research. 2001 Nov;9(11):655-661.
Kim, Doe Young ; Camilleri, Michael ; Murray, Joseph A. ; Stephens, Debra A. ; Levine, James A. ; Burton, Duane D. / Is there a role for gastric accommodation and satiety in asymptomatic obese people?. In: Obesity Research. 2001 ; Vol. 9, No. 11. pp. 655-661.
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