Is sham cTBS real cTBS? The effect on EEG dynamics

Alexander Opitz, Wynn Legon, Jerel Mueller, Aaron Barbour, Walter Paulus, William Tyler

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Increasing sensitivity of modern evaluation tools allows for the study of weaker electric stimulation effects on neural populations. In the current study we examined the effects of sham continuous theta burst (cTBS) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex (DLPFC) upon somatosensory evoked potentials (SEP) and frontal-parietal phase coupling of alpha and beta bands. Sham TMS results in an induced electric field amplitude roughly 5% that of real TMS with a similar spatial extent in cortex. Both real and sham cTBS reduced the amplitude of the frontal P14-N30 SEP and increased local phase coupling in the alpha-beta frequency bands of left frontal cortex. In addition, both sham and real cTBS increased frontal-parietal phase coupling in the alpha-beta bands concomitant with an increase in amplitude of parietal P50-N70 complex. These data suggest that weak electric fields from sham cTBS can affect both local and downstream neuronal circuits, though in a different manner than high strength TMS.

Original languageEnglish (US)
Article number1043
JournalFrontiers in Human Neuroscience
Volume8
Issue numberJAN
DOIs
StatePublished - Jan 8 2015

Fingerprint

Somatosensory Evoked Potentials
Electroencephalography
Transcranial Magnetic Stimulation
Frontal Lobe
Prefrontal Cortex
Electric Stimulation
Population

Keywords

  • DLPFC
  • EEG
  • Electric field
  • Evoked potentials
  • Sham TMS
  • Somatosensory
  • TMS

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neurology
  • Biological Psychiatry
  • Behavioral Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Is sham cTBS real cTBS? The effect on EEG dynamics. / Opitz, Alexander; Legon, Wynn; Mueller, Jerel; Barbour, Aaron; Paulus, Walter; Tyler, William.

In: Frontiers in Human Neuroscience, Vol. 8, No. JAN, 1043, 08.01.2015.

Research output: Contribution to journalArticle

Opitz, A, Legon, W, Mueller, J, Barbour, A, Paulus, W & Tyler, W 2015, 'Is sham cTBS real cTBS? The effect on EEG dynamics', Frontiers in Human Neuroscience, vol. 8, no. JAN, 1043. https://doi.org/10.3389/fnhum.2014.01043
Opitz, Alexander ; Legon, Wynn ; Mueller, Jerel ; Barbour, Aaron ; Paulus, Walter ; Tyler, William. / Is sham cTBS real cTBS? The effect on EEG dynamics. In: Frontiers in Human Neuroscience. 2015 ; Vol. 8, No. JAN.
@article{173ed1471d774d4394c5973dc879b1fc,
title = "Is sham cTBS real cTBS? The effect on EEG dynamics",
abstract = "Increasing sensitivity of modern evaluation tools allows for the study of weaker electric stimulation effects on neural populations. In the current study we examined the effects of sham continuous theta burst (cTBS) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex (DLPFC) upon somatosensory evoked potentials (SEP) and frontal-parietal phase coupling of alpha and beta bands. Sham TMS results in an induced electric field amplitude roughly 5{\%} that of real TMS with a similar spatial extent in cortex. Both real and sham cTBS reduced the amplitude of the frontal P14-N30 SEP and increased local phase coupling in the alpha-beta frequency bands of left frontal cortex. In addition, both sham and real cTBS increased frontal-parietal phase coupling in the alpha-beta bands concomitant with an increase in amplitude of parietal P50-N70 complex. These data suggest that weak electric fields from sham cTBS can affect both local and downstream neuronal circuits, though in a different manner than high strength TMS.",
keywords = "DLPFC, EEG, Electric field, Evoked potentials, Sham TMS, Somatosensory, TMS",
author = "Alexander Opitz and Wynn Legon and Jerel Mueller and Aaron Barbour and Walter Paulus and William Tyler",
year = "2015",
month = "1",
day = "8",
doi = "10.3389/fnhum.2014.01043",
language = "English (US)",
volume = "8",
journal = "Frontiers in Human Neuroscience",
issn = "1662-5161",
publisher = "Frontiers Research Foundation",
number = "JAN",

}

TY - JOUR

T1 - Is sham cTBS real cTBS? The effect on EEG dynamics

AU - Opitz, Alexander

AU - Legon, Wynn

AU - Mueller, Jerel

AU - Barbour, Aaron

AU - Paulus, Walter

AU - Tyler, William

PY - 2015/1/8

Y1 - 2015/1/8

N2 - Increasing sensitivity of modern evaluation tools allows for the study of weaker electric stimulation effects on neural populations. In the current study we examined the effects of sham continuous theta burst (cTBS) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex (DLPFC) upon somatosensory evoked potentials (SEP) and frontal-parietal phase coupling of alpha and beta bands. Sham TMS results in an induced electric field amplitude roughly 5% that of real TMS with a similar spatial extent in cortex. Both real and sham cTBS reduced the amplitude of the frontal P14-N30 SEP and increased local phase coupling in the alpha-beta frequency bands of left frontal cortex. In addition, both sham and real cTBS increased frontal-parietal phase coupling in the alpha-beta bands concomitant with an increase in amplitude of parietal P50-N70 complex. These data suggest that weak electric fields from sham cTBS can affect both local and downstream neuronal circuits, though in a different manner than high strength TMS.

AB - Increasing sensitivity of modern evaluation tools allows for the study of weaker electric stimulation effects on neural populations. In the current study we examined the effects of sham continuous theta burst (cTBS) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex (DLPFC) upon somatosensory evoked potentials (SEP) and frontal-parietal phase coupling of alpha and beta bands. Sham TMS results in an induced electric field amplitude roughly 5% that of real TMS with a similar spatial extent in cortex. Both real and sham cTBS reduced the amplitude of the frontal P14-N30 SEP and increased local phase coupling in the alpha-beta frequency bands of left frontal cortex. In addition, both sham and real cTBS increased frontal-parietal phase coupling in the alpha-beta bands concomitant with an increase in amplitude of parietal P50-N70 complex. These data suggest that weak electric fields from sham cTBS can affect both local and downstream neuronal circuits, though in a different manner than high strength TMS.

KW - DLPFC

KW - EEG

KW - Electric field

KW - Evoked potentials

KW - Sham TMS

KW - Somatosensory

KW - TMS

UR - http://www.scopus.com/inward/record.url?scp=84933671361&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84933671361&partnerID=8YFLogxK

U2 - 10.3389/fnhum.2014.01043

DO - 10.3389/fnhum.2014.01043

M3 - Article

VL - 8

JO - Frontiers in Human Neuroscience

JF - Frontiers in Human Neuroscience

SN - 1662-5161

IS - JAN

M1 - 1043

ER -