Is sham cTBS real cTBS? The effect on EEG dynamics

Alexander Opitz, Wynn Legon, Jerel Mueller, Aaron Barbour, Walter Paulus, William J. Tyler

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Increasing sensitivity of modern evaluation tools allows for the study of weaker electric stimulation effects on neural populations. In the current study we examined the effects of sham continuous theta burst (cTBS) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex (DLPFC) upon somatosensory evoked potentials (SEP) and frontal-parietal phase coupling of alpha and beta bands. Sham TMS results in an induced electric field amplitude roughly 5% that of real TMS with a similar spatial extent in cortex. Both real and sham cTBS reduced the amplitude of the frontal P14-N30 SEP and increased local phase coupling in the alpha-beta frequency bands of left frontal cortex. In addition, both sham and real cTBS increased frontal-parietal phase coupling in the alpha-beta bands concomitant with an increase in amplitude of parietal P50-N70 complex. These data suggest that weak electric fields from sham cTBS can affect both local and downstream neuronal circuits, though in a different manner than high strength TMS.

Original languageEnglish (US)
Article number1043
JournalFrontiers in Human Neuroscience
Volume8
Issue numberJAN
DOIs
StatePublished - Jan 8 2015

Keywords

  • DLPFC
  • EEG
  • Electric field
  • Evoked potentials
  • Sham TMS
  • Somatosensory
  • TMS

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neurology
  • Biological Psychiatry
  • Behavioral Neuroscience
  • Neuropsychology and Physiological Psychology

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