Iron deficiency: Improved exercise performance within 15 hours of iron treatment in rats

W. T. Willis, K. Gohil, G. A. Brooks, P. R. Dallman

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

We tested the hypothesis that a very rapid improvement in exercise performance of iron-deficient rats after treatment with iron might reveal a rate-limiting role of ionic iron as an enzyme cofactor in energy metabolism. Rats were given iron-deficient or control diets after weaning at 21 d of age and intraperitoneal iron dextran (50 mg/kg) at 45 d of age. Time to fatigue during an easy walking exercise (endurance) was measured 15 and 18 h after iron dextran or saline injection. Endurance increased more than threefold compared to the saline-treated, iron-deficient animals without a significant change in hemoglobin concentration. This prompt improvement suggests that lack of cofactor iron might play a metabolically important role in impairing exercise performance in the severely iron-deficient rat.

Original languageEnglish (US)
Pages (from-to)909-916
Number of pages8
JournalJournal of Nutrition
Volume120
Issue number8
DOIs
StatePublished - Jan 1 1990

Keywords

  • Energy metabolism
  • Exercise
  • Iron deficiency
  • Rat

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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