Iron deficiency: Improved exercise performance within 15 hours of iron treatment in rats

W. T. Willis, K. Gohil, G. A. Brooks, P. R. Dallman

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

We tested the hypothesis that a very rapid improvement in exercise performance of iron-deficient rats after treatment with iron might reveal a rate-limiting role of ionic iron as an enzyme cofactor in energy metabolism. Rats were given iron-deficient or control diets after weaning at 21 d of age and intraperitoneal iron dextran (50 mg/kg) at 45 d of age. Time to fatigue during an easy walking exercise (endurance) was measured 15 and 18 h after iron dextran or saline injection. Endurance increased more than threefold compared to the saline-treated, iron-deficient animals without a significant change in hemoglobin concentration. This prompt improvement suggests that lack of cofactor iron might play a metabolically important role in impairing exercise performance in the severely iron-deficient rat.

Original languageEnglish (US)
Pages (from-to)909-916
Number of pages8
JournalJournal of Nutrition
Volume120
Issue number8
StatePublished - 1990
Externally publishedYes

Fingerprint

exercise
Iron
iron
rats
Therapeutics
dextran
dextran - saline drug combination
Coenzymes
Weaning
Dextrans
walking
energy metabolism
Energy Metabolism
Walking
Fatigue
hemoglobin
weaning
Hemoglobins
Diet
injection

Keywords

  • Energy metabolism
  • Exercise
  • Iron deficiency
  • Rat

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Willis, W. T., Gohil, K., Brooks, G. A., & Dallman, P. R. (1990). Iron deficiency: Improved exercise performance within 15 hours of iron treatment in rats. Journal of Nutrition, 120(8), 909-916.

Iron deficiency : Improved exercise performance within 15 hours of iron treatment in rats. / Willis, W. T.; Gohil, K.; Brooks, G. A.; Dallman, P. R.

In: Journal of Nutrition, Vol. 120, No. 8, 1990, p. 909-916.

Research output: Contribution to journalArticle

Willis, WT, Gohil, K, Brooks, GA & Dallman, PR 1990, 'Iron deficiency: Improved exercise performance within 15 hours of iron treatment in rats', Journal of Nutrition, vol. 120, no. 8, pp. 909-916.
Willis, W. T. ; Gohil, K. ; Brooks, G. A. ; Dallman, P. R. / Iron deficiency : Improved exercise performance within 15 hours of iron treatment in rats. In: Journal of Nutrition. 1990 ; Vol. 120, No. 8. pp. 909-916.
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