Ipsilesional trajectory control is related to contralesional arm paralysis after left hemisphere damage

Kathleen Y. Haaland, Sydney Schaefer, Robert T. Knight, John Adair, Alvaro Magalhaes, Joseph Sadek, Robert L. Sainburg

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We have recently shown ipsilateral dynamic deficits in trajectory control are present in left hemisphere damaged (LHD) patients with paresis, as evidenced by impaired modulation of torque amplitude as response amplitude increases. The purpose of the current study is to determine if these ipsilateral deficits are more common with contralateral hemiparesis and greater damage to the motor system, as evidenced by structural imaging. Three groups of right-handed subjects (healthy controls, LHD stroke patients with and without upper extremity paresis) performed single-joint elbow movements of varying amplitudes with their left arm in the left hemispace. Only the paretic group demonstrated dynamic deficits characterized by decreased modulation of peak torque (reflected by peak acceleration changes) as response amplitude increased. These results could not be attributed to lesion volume or peak velocity as neither variable differed across the groups. However, the paretic group had damage to a larger number of areas within the motor system than the non-paretic group suggesting that such damage increases the probability of ipsilesional deficits in dynamic control for modulating torque amplitude after left hemisphere damage.

Original languageEnglish (US)
Pages (from-to)195-204
Number of pages10
JournalExperimental Brain Research
Volume196
Issue number2
DOIs
StatePublished - Jun 2009
Externally publishedYes

Fingerprint

Torque
Paresis
Paralysis
Elbow Joint
Motor Cortex
Healthy Volunteers
Stroke

Keywords

  • Hemiparesis
  • Hemisphere
  • Hemisphere, arm paralysis
  • Ipsilateral impairment
  • Motor control
  • Motor cortex, premotor cortex, motor performance
  • Paresis, lateralization
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ipsilesional trajectory control is related to contralesional arm paralysis after left hemisphere damage. / Haaland, Kathleen Y.; Schaefer, Sydney; Knight, Robert T.; Adair, John; Magalhaes, Alvaro; Sadek, Joseph; Sainburg, Robert L.

In: Experimental Brain Research, Vol. 196, No. 2, 06.2009, p. 195-204.

Research output: Contribution to journalArticle

Haaland, Kathleen Y. ; Schaefer, Sydney ; Knight, Robert T. ; Adair, John ; Magalhaes, Alvaro ; Sadek, Joseph ; Sainburg, Robert L. / Ipsilesional trajectory control is related to contralesional arm paralysis after left hemisphere damage. In: Experimental Brain Research. 2009 ; Vol. 196, No. 2. pp. 195-204.
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