TY - JOUR
T1 - Ion-exchange selectivity of diclofenac, ibuprofen, ketoprofen, and naproxen in ureolyzed human urine
AU - Landry, Kelly A.
AU - Sun, Peizhe
AU - Huang, Ching Hua
AU - Boyer, Treavor H.
N1 - Funding Information:
The authors would like to thank Nicole Rivera for her assistance with sampling and experiments. This material is based upon work supported by the National Science Foundation Graduate Research Fellowship under Grant No. DGE-1315138 and the NSF CAREER grant CBET-1150790 . Any opinions, findings, conclusions or recommendations expressed in this publication are those of the authors and do not necessarily reflect the views of NSF. KAL also received support from the Glick Scholarship at the University of Florida and the FRWA Curtis E. Lloyd Scholarship. This article was improved by the thoughtful comments of two anonymous reviewers.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - This research advances the knowledge of ion-exchange of four non-steroidal anti-inflammatory drugs (NSAIDs) - diclofenac (DCF), ibuprofen (IBP), ketoprofen (KTP), and naproxen (NPX) - and one analgesic drug-paracetamol (PCM) - by strong-base anion exchange resin (AER) in synthetic ureolyzed urine. Freundlich, Langmuir, Dubinin-Astakhov, and Dubinin-Radushkevich isotherm models were fit to experimental equilibrium data using nonlinear least squares method. Favorable ion-exchange was observed for DCF, KTP, and NPX, whereas unfavorable ion-exchange was observed for IBP and PCM. The ion-exchange selectivity of the AER was enhanced by van der Waals interactions between the pharmaceutical and AER as well as the hydrophobicity of the pharmaceutical. For instance, the high selectivity of the AER for DCF was due to the combination of Coulombic interactions between quaternary ammonium functional group of resin and carboxylate functional group of DCF, van der Waals interactions between polystyrene resin matrix and benzene rings of DCF, and possibly hydrogen bonding between dimethylethanol amine functional group side chain and carboxylate and amine functional groups of DCF. Based on analysis of covariance, the presence of multiple pharmaceuticals did not have a significant effect on ion-exchange removal when the NSAIDs were combined in solution. The AER reached saturation of the pharmaceuticals in a continuous-flow column at varying bed volumes following a decreasing order of DCF>NPX=KTP>IBP. Complete regeneration of the column was achieved using a 5% (m/m) NaCl, equal-volume water-methanol solution. Results from multiple treatment and regeneration cycles provide insight into the practical application of pharmaceutical ion-exchange in ureolyzed urine using AER.
AB - This research advances the knowledge of ion-exchange of four non-steroidal anti-inflammatory drugs (NSAIDs) - diclofenac (DCF), ibuprofen (IBP), ketoprofen (KTP), and naproxen (NPX) - and one analgesic drug-paracetamol (PCM) - by strong-base anion exchange resin (AER) in synthetic ureolyzed urine. Freundlich, Langmuir, Dubinin-Astakhov, and Dubinin-Radushkevich isotherm models were fit to experimental equilibrium data using nonlinear least squares method. Favorable ion-exchange was observed for DCF, KTP, and NPX, whereas unfavorable ion-exchange was observed for IBP and PCM. The ion-exchange selectivity of the AER was enhanced by van der Waals interactions between the pharmaceutical and AER as well as the hydrophobicity of the pharmaceutical. For instance, the high selectivity of the AER for DCF was due to the combination of Coulombic interactions between quaternary ammonium functional group of resin and carboxylate functional group of DCF, van der Waals interactions between polystyrene resin matrix and benzene rings of DCF, and possibly hydrogen bonding between dimethylethanol amine functional group side chain and carboxylate and amine functional groups of DCF. Based on analysis of covariance, the presence of multiple pharmaceuticals did not have a significant effect on ion-exchange removal when the NSAIDs were combined in solution. The AER reached saturation of the pharmaceuticals in a continuous-flow column at varying bed volumes following a decreasing order of DCF>NPX=KTP>IBP. Complete regeneration of the column was achieved using a 5% (m/m) NaCl, equal-volume water-methanol solution. Results from multiple treatment and regeneration cycles provide insight into the practical application of pharmaceutical ion-exchange in ureolyzed urine using AER.
KW - Coulombic interactions
KW - Ion-exchange
KW - Non-steroidal anti-inflammatory drugs
KW - Pharmaceuticals
KW - Urine source separation
KW - Van der Waals forces
UR - http://www.scopus.com/inward/record.url?scp=84910091527&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84910091527&partnerID=8YFLogxK
U2 - 10.1016/j.watres.2014.09.056
DO - 10.1016/j.watres.2014.09.056
M3 - Article
C2 - 25462757
AN - SCOPUS:84910091527
VL - 68
SP - 510
EP - 521
JO - Water Research
JF - Water Research
SN - 0043-1354
ER -