Investigation of water-soluble x-ray luminescence nanoparticles for photodynamic activation

Yuanfang Liu; Wei Chen; Shaopeng Wang; Alan G. Joly

doi:10.1063/1.2835701

Investigation of water-soluble x-ray luminescence nanoparticles for photodynamic activation

Yuanfang Liu, Wei Chen, Shaopeng Wang, Alan G. Joly

Research output: Contribution to journal › Article › peer-review

222 Scopus citations

Abstract

In this letter, we report the synthesis of La F3: Tb3+ -meso-tetra(4- carboxyphenyl) porphine (MTCP) nanoparticle conjugates and investigate the energy transfer as well as singlet oxygen generation following x-ray irradiation. Our observations indicate that La F3: Tb3+ -MTCP nanoparticle conjugates are efficient photodynamic agents that can be initiated by x-rays at a reasonably low dose. The addition of folic acid to facilitate targeting to folate receptors on tumor cells has no effect on the quantum yield of singlet oxygen production in the nanoparticle-MTCP conjugates. Our pilot studies indicate that water-soluble scintillation nanoparticles can potentially be used to activate photodynamic therapy as a promising deep cancer treatment modality.

Original language	English (US)
Article number	043901
Journal	Applied Physics Letters
Volume	92
Issue number	4
DOIs	https://doi.org/10.1063/1.2835701
State	Published - 2008
Externally published	Yes

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.2835701

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title = "Investigation of water-soluble x-ray luminescence nanoparticles for photodynamic activation",

abstract = "In this letter, we report the synthesis of La F3: Tb3+ -meso-tetra(4- carboxyphenyl) porphine (MTCP) nanoparticle conjugates and investigate the energy transfer as well as singlet oxygen generation following x-ray irradiation. Our observations indicate that La F3: Tb3+ -MTCP nanoparticle conjugates are efficient photodynamic agents that can be initiated by x-rays at a reasonably low dose. The addition of folic acid to facilitate targeting to folate receptors on tumor cells has no effect on the quantum yield of singlet oxygen production in the nanoparticle-MTCP conjugates. Our pilot studies indicate that water-soluble scintillation nanoparticles can potentially be used to activate photodynamic therapy as a promising deep cancer treatment modality.",

author = "Yuanfang Liu and Wei Chen and Shaopeng Wang and Joly, {Alan G.}",

note = "Funding Information: This project is supported by the U.S. Army Medical Research Acquisition Activity (W81XWH-05-C-0101), and partially by the NSF and DHS joint program (CBET-0736172) as well as by DOE (DE-AC06-76RLO1830).",

year = "2008",

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T1 - Investigation of water-soluble x-ray luminescence nanoparticles for photodynamic activation

AU - Liu, Yuanfang

AU - Chen, Wei

AU - Wang, Shaopeng

AU - Joly, Alan G.

N1 - Funding Information: This project is supported by the U.S. Army Medical Research Acquisition Activity (W81XWH-05-C-0101), and partially by the NSF and DHS joint program (CBET-0736172) as well as by DOE (DE-AC06-76RLO1830).

PY - 2008

Y1 - 2008

N2 - In this letter, we report the synthesis of La F3: Tb3+ -meso-tetra(4- carboxyphenyl) porphine (MTCP) nanoparticle conjugates and investigate the energy transfer as well as singlet oxygen generation following x-ray irradiation. Our observations indicate that La F3: Tb3+ -MTCP nanoparticle conjugates are efficient photodynamic agents that can be initiated by x-rays at a reasonably low dose. The addition of folic acid to facilitate targeting to folate receptors on tumor cells has no effect on the quantum yield of singlet oxygen production in the nanoparticle-MTCP conjugates. Our pilot studies indicate that water-soluble scintillation nanoparticles can potentially be used to activate photodynamic therapy as a promising deep cancer treatment modality.

AB - In this letter, we report the synthesis of La F3: Tb3+ -meso-tetra(4- carboxyphenyl) porphine (MTCP) nanoparticle conjugates and investigate the energy transfer as well as singlet oxygen generation following x-ray irradiation. Our observations indicate that La F3: Tb3+ -MTCP nanoparticle conjugates are efficient photodynamic agents that can be initiated by x-rays at a reasonably low dose. The addition of folic acid to facilitate targeting to folate receptors on tumor cells has no effect on the quantum yield of singlet oxygen production in the nanoparticle-MTCP conjugates. Our pilot studies indicate that water-soluble scintillation nanoparticles can potentially be used to activate photodynamic therapy as a promising deep cancer treatment modality.

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JO - Applied Physics Letters

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ER -

Investigation of water-soluble x-ray luminescence nanoparticles for photodynamic activation

Abstract

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