@inproceedings{a160af704bd84b299190a1c5a24bf63a,
title = "Investigating the Effect of Tau Deposition and Apoe on Hippocampal Morphometry in Alzheimer's Disease: A Federated Chow Test Model",
abstract = "Alzheimer's disease (AD) affects more than 1 in 9 people age 65 and older and becomes an urgent public health concern as the global population ages. Tau tangle is the specific protein pathological hallmark of AD and plays a crucial role in leading to dementia-related structural deformations observed in magnetic resonance imaging (MRI) scans. The volume loss of hippocampus is mainly related to the development of AD. Besides, apolipoprotein E (APOE) also has significant effects on the risk of developing AD. However, few studies focus on integrating genotypes, MRI, and tau deposition to infer multimodal relationships. In this paper, we proposed a federated chow test model to study the synergistic effects of APOE and tau on hippocampal morphometry. Our experimental results demonstrate our model can detect the difference of tau deposition and hippocampal atrophy among the cohorts with different genotypes and subiculum and cornu ammonis 1 (CA1 subfield) were identified as hippocampal subregions where atrophy is strongly associated with abnormal tau in the homozygote cohort. Our model will provide novel insight into the neural mechanisms about the individual impact of APOE and tau deposition on brain imaging.",
keywords = "APOE, Alzheimer's Disease, Hippocampal Morphometry, federated chow test, tau deposition",
author = "Jianfeng Wu and Yi Su and Reiman, {Eric M.} and Caselli, {Richard J.} and Kewei Chen and Thompson, {Paul M.} and Junwen Wang and Yalin Wang",
note = "Funding Information: In this paper, we proposed a federated model to investigate the effect of tau deposition and APOE on hippocampal morphometry in AD. In the future, we will use this model to study Aβ and AD-related SNP, like rs11136000 on CLU. 6. ACKNOWLEDGMENTS The work was supported by ASU/Mayo Seed Grant Program, National Institute on Aging (R21AG065942, U01AG068057, R01AG069453, and P30AG072980), National Library of Medicine (R01LM013438), National Institute of Biomedical Imaging and Bioengineering (R01EB025032), National Eye Institute (R01EY032125), National Institute of Dental and Craniofacial Research (R01DE030286), Arizona Alzheimer Consortium. 7. COMPLIANCE WITH ETHICAL STANDARDS This research study was conducted retrospectively using human subject data made available in open access by ADNI. Ethical approval was not enquired as confirmed by the license attached with the open access data. Publisher Copyright: {\textcopyright} 2022 IEEE.; 19th IEEE International Symposium on Biomedical Imaging, ISBI 2022 ; Conference date: 28-03-2022 Through 31-03-2022",
year = "2022",
doi = "10.1109/ISBI52829.2022.9761576",
language = "English (US)",
series = "Proceedings - International Symposium on Biomedical Imaging",
publisher = "IEEE Computer Society",
booktitle = "ISBI 2022 - Proceedings",
}