Introductory essay: Evolution, comparative biology, and development

William C. Aird, Manfred Laubichler

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

WHY STUDY EVOLUTION? An understanding of the evolutionary origins of the endothelium has important implications for human health and disease. As discussed by Nesse and Weder (Chapter 15), when approaching mechanisms of structure and function, evolutionary explanations (“why”) complement proximate considerations (“how”). They provide important insights into the design constraints, path dependence, trade-offs, and selective pressures that underlie endothelial function and vulnerability to disease. Another critical and often underappreciated consideration is that, in the course of human evolution, our body (including the endothelium) has evolved to maximize fitness in a far earlier era, perhaps tens of thousands of years ago, which is the time it takes for the gene pool to be filtered by natural selection. In Chapter 16, Eaton and his colleagues write about the environment and lifestyle of the hunter-gatherer, and remind us about the importance of cultural (as distinct from genetic) evolution in mediating the modern-day predisposition to atherosclerosis. As another example of how evolutionary theory may be applied to an understanding of human disease, Haig discusses how evolutionary conflicts between maternal and fetal genes may underlie the pathophysiology of preeclampsia (Chapter 17). Piecing together the evolutionary origins of the endothelium is challenging and necessarily speculative. Because the human endothelium does not fossilize, interpretations rely on a combination of molecular phylogeny and comparative biology/physiology, with the assumption that what works for extant organisms may have worked for ancestral species. In Chapter 14, McVey demonstrates how molecular phylogenetic approaches may be used to gain insights into the evolutionary history of the endothelium. In Chapter 3, Burggren and Reiber provide a comprehensive overview of the comparative biology of cardiovascular systems.

Original languageEnglish (US)
Title of host publicationEndothelial Biomedicine
PublisherCambridge University Press
Pages21-28
Number of pages8
Volume9780521853767
ISBN (Print)9780511546198, 0521853761, 9780521853767
DOIs
StatePublished - Jan 1 2007

Fingerprint

Endothelium
Genes
Cardiovascular system
Physiology
Comparative Physiology
Gene Pool
History
Health
Molecular Evolution
Genetic Selection
Phylogeny
Cardiovascular System
Pre-Eclampsia
Life Style
Atherosclerosis
Mothers

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Aird, W. C., & Laubichler, M. (2007). Introductory essay: Evolution, comparative biology, and development. In Endothelial Biomedicine (Vol. 9780521853767, pp. 21-28). Cambridge University Press. https://doi.org/10.1017/CBO9780511546198.003

Introductory essay : Evolution, comparative biology, and development. / Aird, William C.; Laubichler, Manfred.

Endothelial Biomedicine. Vol. 9780521853767 Cambridge University Press, 2007. p. 21-28.

Research output: Chapter in Book/Report/Conference proceedingChapter

Aird, WC & Laubichler, M 2007, Introductory essay: Evolution, comparative biology, and development. in Endothelial Biomedicine. vol. 9780521853767, Cambridge University Press, pp. 21-28. https://doi.org/10.1017/CBO9780511546198.003
Aird WC, Laubichler M. Introductory essay: Evolution, comparative biology, and development. In Endothelial Biomedicine. Vol. 9780521853767. Cambridge University Press. 2007. p. 21-28 https://doi.org/10.1017/CBO9780511546198.003
Aird, William C. ; Laubichler, Manfred. / Introductory essay : Evolution, comparative biology, and development. Endothelial Biomedicine. Vol. 9780521853767 Cambridge University Press, 2007. pp. 21-28
@inbook{4245ca7ecf1048afa8e7ca749ade3a35,
title = "Introductory essay: Evolution, comparative biology, and development",
abstract = "WHY STUDY EVOLUTION? An understanding of the evolutionary origins of the endothelium has important implications for human health and disease. As discussed by Nesse and Weder (Chapter 15), when approaching mechanisms of structure and function, evolutionary explanations (“why”) complement proximate considerations (“how”). They provide important insights into the design constraints, path dependence, trade-offs, and selective pressures that underlie endothelial function and vulnerability to disease. Another critical and often underappreciated consideration is that, in the course of human evolution, our body (including the endothelium) has evolved to maximize fitness in a far earlier era, perhaps tens of thousands of years ago, which is the time it takes for the gene pool to be filtered by natural selection. In Chapter 16, Eaton and his colleagues write about the environment and lifestyle of the hunter-gatherer, and remind us about the importance of cultural (as distinct from genetic) evolution in mediating the modern-day predisposition to atherosclerosis. As another example of how evolutionary theory may be applied to an understanding of human disease, Haig discusses how evolutionary conflicts between maternal and fetal genes may underlie the pathophysiology of preeclampsia (Chapter 17). Piecing together the evolutionary origins of the endothelium is challenging and necessarily speculative. Because the human endothelium does not fossilize, interpretations rely on a combination of molecular phylogeny and comparative biology/physiology, with the assumption that what works for extant organisms may have worked for ancestral species. In Chapter 14, McVey demonstrates how molecular phylogenetic approaches may be used to gain insights into the evolutionary history of the endothelium. In Chapter 3, Burggren and Reiber provide a comprehensive overview of the comparative biology of cardiovascular systems.",
author = "Aird, {William C.} and Manfred Laubichler",
year = "2007",
month = "1",
day = "1",
doi = "10.1017/CBO9780511546198.003",
language = "English (US)",
isbn = "9780511546198",
volume = "9780521853767",
pages = "21--28",
booktitle = "Endothelial Biomedicine",
publisher = "Cambridge University Press",

}

TY - CHAP

T1 - Introductory essay

T2 - Evolution, comparative biology, and development

AU - Aird, William C.

AU - Laubichler, Manfred

PY - 2007/1/1

Y1 - 2007/1/1

N2 - WHY STUDY EVOLUTION? An understanding of the evolutionary origins of the endothelium has important implications for human health and disease. As discussed by Nesse and Weder (Chapter 15), when approaching mechanisms of structure and function, evolutionary explanations (“why”) complement proximate considerations (“how”). They provide important insights into the design constraints, path dependence, trade-offs, and selective pressures that underlie endothelial function and vulnerability to disease. Another critical and often underappreciated consideration is that, in the course of human evolution, our body (including the endothelium) has evolved to maximize fitness in a far earlier era, perhaps tens of thousands of years ago, which is the time it takes for the gene pool to be filtered by natural selection. In Chapter 16, Eaton and his colleagues write about the environment and lifestyle of the hunter-gatherer, and remind us about the importance of cultural (as distinct from genetic) evolution in mediating the modern-day predisposition to atherosclerosis. As another example of how evolutionary theory may be applied to an understanding of human disease, Haig discusses how evolutionary conflicts between maternal and fetal genes may underlie the pathophysiology of preeclampsia (Chapter 17). Piecing together the evolutionary origins of the endothelium is challenging and necessarily speculative. Because the human endothelium does not fossilize, interpretations rely on a combination of molecular phylogeny and comparative biology/physiology, with the assumption that what works for extant organisms may have worked for ancestral species. In Chapter 14, McVey demonstrates how molecular phylogenetic approaches may be used to gain insights into the evolutionary history of the endothelium. In Chapter 3, Burggren and Reiber provide a comprehensive overview of the comparative biology of cardiovascular systems.

AB - WHY STUDY EVOLUTION? An understanding of the evolutionary origins of the endothelium has important implications for human health and disease. As discussed by Nesse and Weder (Chapter 15), when approaching mechanisms of structure and function, evolutionary explanations (“why”) complement proximate considerations (“how”). They provide important insights into the design constraints, path dependence, trade-offs, and selective pressures that underlie endothelial function and vulnerability to disease. Another critical and often underappreciated consideration is that, in the course of human evolution, our body (including the endothelium) has evolved to maximize fitness in a far earlier era, perhaps tens of thousands of years ago, which is the time it takes for the gene pool to be filtered by natural selection. In Chapter 16, Eaton and his colleagues write about the environment and lifestyle of the hunter-gatherer, and remind us about the importance of cultural (as distinct from genetic) evolution in mediating the modern-day predisposition to atherosclerosis. As another example of how evolutionary theory may be applied to an understanding of human disease, Haig discusses how evolutionary conflicts between maternal and fetal genes may underlie the pathophysiology of preeclampsia (Chapter 17). Piecing together the evolutionary origins of the endothelium is challenging and necessarily speculative. Because the human endothelium does not fossilize, interpretations rely on a combination of molecular phylogeny and comparative biology/physiology, with the assumption that what works for extant organisms may have worked for ancestral species. In Chapter 14, McVey demonstrates how molecular phylogenetic approaches may be used to gain insights into the evolutionary history of the endothelium. In Chapter 3, Burggren and Reiber provide a comprehensive overview of the comparative biology of cardiovascular systems.

UR - http://www.scopus.com/inward/record.url?scp=84856962917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856962917&partnerID=8YFLogxK

U2 - 10.1017/CBO9780511546198.003

DO - 10.1017/CBO9780511546198.003

M3 - Chapter

AN - SCOPUS:84856962917

SN - 9780511546198

SN - 0521853761

SN - 9780521853767

VL - 9780521853767

SP - 21

EP - 28

BT - Endothelial Biomedicine

PB - Cambridge University Press

ER -