Abstract
An intravascular carbon dioxide sensor is investigated which employs continuous perfusion of micro-quantities of reagent through silicone membrane tubing in contact with blood. Blood is sampled from a vessel by periodic withdrawal-reinfusion through a catheter and passes by the sensor membrane tubing integrated into the catheter system. Blood CO2 equilibrates across the silicone membrane causing a color change in the reagent micro-flow stream that is detected by an optical cell external to the vessel. In vivo trials on pigs demonstrate a stable sensor response, a fast response time, and high signal-to-noise ratios. The sensor also exhibits an immunity to temperature changes, reduced intravascular blood flow, photobleaching, and leaching. It has a 2 min response time, a ±2 mmHg resolution, and minimal drift over a 12 h duration. Using a pig model, measured values compared with true values indicate a 0.998 correlation coefficient, a 1.3 mmHg precision, and a 1.7 mmHg bias.
Original language | English (US) |
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Pages (from-to) | 11-17 |
Number of pages | 7 |
Journal | Biosensors and Bioelectronics |
Volume | 12 |
Issue number | 1 |
DOIs | |
State | Published - 1997 |
Keywords
- Carbon dioxide
- Colorimetry
- Micro-flow
- Microdialysis
- Optical detection,
- Withdrawal-reinfusion
ASJC Scopus subject areas
- Biotechnology
- Biophysics
- Biomedical Engineering
- Electrochemistry