Intrahepatic metastases may be specific to hepatocellular carcinoma due to the coagulation and fibrinolytic systems (Review)

Xuemei Li, Baohong Gu, Bofang Wang, Zedong Feng, Yanling Ma, Haiyuan Li, Alexandra Lucas, Hao Chen

Research output: Contribution to journalReview articlepeer-review

Abstract

Hepatocellular carcinoma (HCC) is different from other solid tumors because it is commonly associated with the occurrence of intrahepatic metastasis. Additionally, the liver, unlike other organs, is the main site of coagulation and fibrinolytic factor production. Therefore, it was speculated that coagulation and fibrinolytic factors could be associated with intrahepatic metastasis of HCC. Do the coagulation and fibrinolytic systems protect HCC cells against anoikis during infiltration and metastasis? Conversely, do the coagulation and fibrinolytic systems lead to immune escape of HCC cells by affecting the immune microenvironment of patients? The current review aimed to present a number of novel hypotheses for the treatment of HCC by exploring the mechanisms of coagulation and fibrinolytic factors in the regulation of cancer growth.

Original languageEnglish (US)
Pages (from-to)2345-2352
Number of pages8
JournalOncology Reports
Volume44
Issue number6
DOIs
StatePublished - Dec 2020

Keywords

  • Anti-anoikis
  • Coagulation-fibrinolytic system
  • Hepatocellular carcinoma
  • Immune escape
  • Intrahepatic metastasis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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