Intracellular amyloid-β in Alzheimer's disease

Frank M. LaFerla, Kim N. Green, Salvatore Oddo

Research output: Contribution to journalArticle

1234 Citations (Scopus)

Abstract

The primal role that the amyloid-β (Aβ) peptide has in the development of Alzheimer's disease is now almost universally accepted. It is also well recognized that Aβ exists in multiple assembly states, which have different physiological or pathophysiological effects. Although the classical view is that Aβ is deposited extracellularly, emerging evidence from transgenic mice and human patients indicates that this peptide can also accumulate intraneuronally, which may contribute to disease progression.

Original languageEnglish (US)
Pages (from-to)499-509
Number of pages11
JournalNature Reviews Neuroscience
Volume8
Issue number7
DOIs
StatePublished - Jul 2007
Externally publishedYes

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Amyloid
Alzheimer Disease
Peptides
Transgenic Mice
Disease Progression

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cell Biology

Cite this

Intracellular amyloid-β in Alzheimer's disease. / LaFerla, Frank M.; Green, Kim N.; Oddo, Salvatore.

In: Nature Reviews Neuroscience, Vol. 8, No. 7, 07.2007, p. 499-509.

Research output: Contribution to journalArticle

LaFerla, Frank M. ; Green, Kim N. ; Oddo, Salvatore. / Intracellular amyloid-β in Alzheimer's disease. In: Nature Reviews Neuroscience. 2007 ; Vol. 8, No. 7. pp. 499-509.
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