Intracellular amyloid-β in Alzheimer's disease

Frank M. LaFerla, Kim N. Green, Salvatore Oddo

Research output: Contribution to journalReview articlepeer-review

1461 Scopus citations

Abstract

The primal role that the amyloid-β (Aβ) peptide has in the development of Alzheimer's disease is now almost universally accepted. It is also well recognized that Aβ exists in multiple assembly states, which have different physiological or pathophysiological effects. Although the classical view is that Aβ is deposited extracellularly, emerging evidence from transgenic mice and human patients indicates that this peptide can also accumulate intraneuronally, which may contribute to disease progression.

Original languageEnglish (US)
Pages (from-to)499-509
Number of pages11
JournalNature Reviews Neuroscience
Volume8
Issue number7
DOIs
StatePublished - Jul 2007
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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