Interactions between serotonin transporter gene haplotypes and quality of mothers' parenting predict the development of children's noncompliance

Michael J. Sulik, Nancy Eisenberg, Kathryn Lemery, Tracy Spinrad, Kassondra M. Silva, Natalie Wilkens, Jennifer A. Betkowski, Anne Kupfer, Cynthia L. Smith, Bridget Gaertner, Daryn A. Stover, Brian C. Verrelli

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The LPR and STin2 polymorphisms of the serotonin transporter gene (SLC6A4) were combined into haplotypes that, together with quality of maternal parenting, were used to predict initial levels and linear change in children's (N = 138) noncompliance and aggression from age 18-54 months. Quality of mothers' parenting behavior was observed when children were 18 months old, and nonparental caregivers' reports of noncompliance and aggression were collected annually from 18 to 54 months of age. Quality of early parenting was negatively related to the slope of noncompliance only for children with the LPR-S/STin2-10 haplotype and to 18-month noncompliance only for children with haplotypes that did not include LPR-S. The findings support the notion that SLC6A4 haplotypes index differential susceptibility to variability in parenting quality, with certain haplotypes showing greater reactivity to both supportive and unsupportive environments. These different genetic backgrounds likely reflect an evolutionary response to variation in the parenting environment.

Original languageEnglish (US)
Pages (from-to)740-754
Number of pages15
JournalDevelopmental Psychology
Volume48
Issue number3
DOIs
StatePublished - May 2012

Fingerprint

Serotonin Plasma Membrane Transport Proteins
Parenting
Child Development
Haplotypes
Mothers
interaction
aggression
Genes
Aggression
caregiver
Caregivers

Keywords

  • Aggression
  • Differential susceptibility
  • Noncompliance
  • Serotonin transporter gene
  • SLC6A4 (5-HTT)

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Life-span and Life-course Studies
  • Demography

Cite this

Interactions between serotonin transporter gene haplotypes and quality of mothers' parenting predict the development of children's noncompliance. / Sulik, Michael J.; Eisenberg, Nancy; Lemery, Kathryn; Spinrad, Tracy; Silva, Kassondra M.; Wilkens, Natalie; Betkowski, Jennifer A.; Kupfer, Anne; Smith, Cynthia L.; Gaertner, Bridget; Stover, Daryn A.; Verrelli, Brian C.

In: Developmental Psychology, Vol. 48, No. 3, 05.2012, p. 740-754.

Research output: Contribution to journalArticle

Sulik, Michael J. ; Eisenberg, Nancy ; Lemery, Kathryn ; Spinrad, Tracy ; Silva, Kassondra M. ; Wilkens, Natalie ; Betkowski, Jennifer A. ; Kupfer, Anne ; Smith, Cynthia L. ; Gaertner, Bridget ; Stover, Daryn A. ; Verrelli, Brian C. / Interactions between serotonin transporter gene haplotypes and quality of mothers' parenting predict the development of children's noncompliance. In: Developmental Psychology. 2012 ; Vol. 48, No. 3. pp. 740-754.
@article{19858e3500de497bafe418fc11590588,
title = "Interactions between serotonin transporter gene haplotypes and quality of mothers' parenting predict the development of children's noncompliance",
abstract = "The LPR and STin2 polymorphisms of the serotonin transporter gene (SLC6A4) were combined into haplotypes that, together with quality of maternal parenting, were used to predict initial levels and linear change in children's (N = 138) noncompliance and aggression from age 18-54 months. Quality of mothers' parenting behavior was observed when children were 18 months old, and nonparental caregivers' reports of noncompliance and aggression were collected annually from 18 to 54 months of age. Quality of early parenting was negatively related to the slope of noncompliance only for children with the LPR-S/STin2-10 haplotype and to 18-month noncompliance only for children with haplotypes that did not include LPR-S. The findings support the notion that SLC6A4 haplotypes index differential susceptibility to variability in parenting quality, with certain haplotypes showing greater reactivity to both supportive and unsupportive environments. These different genetic backgrounds likely reflect an evolutionary response to variation in the parenting environment.",
keywords = "Aggression, Differential susceptibility, Noncompliance, Serotonin transporter gene, SLC6A4 (5-HTT)",
author = "Sulik, {Michael J.} and Nancy Eisenberg and Kathryn Lemery and Tracy Spinrad and Silva, {Kassondra M.} and Natalie Wilkens and Betkowski, {Jennifer A.} and Anne Kupfer and Smith, {Cynthia L.} and Bridget Gaertner and Stover, {Daryn A.} and Verrelli, {Brian C.}",
year = "2012",
month = "5",
doi = "10.1037/a0025938",
language = "English (US)",
volume = "48",
pages = "740--754",
journal = "Developmental Psychology",
issn = "0012-1649",
publisher = "American Psychological Association Inc.",
number = "3",

}

TY - JOUR

T1 - Interactions between serotonin transporter gene haplotypes and quality of mothers' parenting predict the development of children's noncompliance

AU - Sulik, Michael J.

AU - Eisenberg, Nancy

AU - Lemery, Kathryn

AU - Spinrad, Tracy

AU - Silva, Kassondra M.

AU - Wilkens, Natalie

AU - Betkowski, Jennifer A.

AU - Kupfer, Anne

AU - Smith, Cynthia L.

AU - Gaertner, Bridget

AU - Stover, Daryn A.

AU - Verrelli, Brian C.

PY - 2012/5

Y1 - 2012/5

N2 - The LPR and STin2 polymorphisms of the serotonin transporter gene (SLC6A4) were combined into haplotypes that, together with quality of maternal parenting, were used to predict initial levels and linear change in children's (N = 138) noncompliance and aggression from age 18-54 months. Quality of mothers' parenting behavior was observed when children were 18 months old, and nonparental caregivers' reports of noncompliance and aggression were collected annually from 18 to 54 months of age. Quality of early parenting was negatively related to the slope of noncompliance only for children with the LPR-S/STin2-10 haplotype and to 18-month noncompliance only for children with haplotypes that did not include LPR-S. The findings support the notion that SLC6A4 haplotypes index differential susceptibility to variability in parenting quality, with certain haplotypes showing greater reactivity to both supportive and unsupportive environments. These different genetic backgrounds likely reflect an evolutionary response to variation in the parenting environment.

AB - The LPR and STin2 polymorphisms of the serotonin transporter gene (SLC6A4) were combined into haplotypes that, together with quality of maternal parenting, were used to predict initial levels and linear change in children's (N = 138) noncompliance and aggression from age 18-54 months. Quality of mothers' parenting behavior was observed when children were 18 months old, and nonparental caregivers' reports of noncompliance and aggression were collected annually from 18 to 54 months of age. Quality of early parenting was negatively related to the slope of noncompliance only for children with the LPR-S/STin2-10 haplotype and to 18-month noncompliance only for children with haplotypes that did not include LPR-S. The findings support the notion that SLC6A4 haplotypes index differential susceptibility to variability in parenting quality, with certain haplotypes showing greater reactivity to both supportive and unsupportive environments. These different genetic backgrounds likely reflect an evolutionary response to variation in the parenting environment.

KW - Aggression

KW - Differential susceptibility

KW - Noncompliance

KW - Serotonin transporter gene

KW - SLC6A4 (5-HTT)

UR - http://www.scopus.com/inward/record.url?scp=84864260973&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864260973&partnerID=8YFLogxK

U2 - 10.1037/a0025938

DO - 10.1037/a0025938

M3 - Article

C2 - 22059451

AN - SCOPUS:84864260973

VL - 48

SP - 740

EP - 754

JO - Developmental Psychology

JF - Developmental Psychology

SN - 0012-1649

IS - 3

ER -