Interactions among catechol-O-methyltransferase genotype, parenting, and sex predict children's internalizing symptoms and inhibitory control: Evidence for differential susceptibility

Michael J. Sulik, Nancy Eisenberg, Tracy Spinrad, Kathryn Lemery, Gregory Swann, Kassondra M. Silva, Mark Reiser, Daryn A. Stover, Brian C. Verrelli

Research output: Contribution to journalArticle

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Abstract

We used sex, observed parenting quality at 18 months, and three variants of the catechol-O-methyltransferase gene (Val<sup>158</sup>Met [rs4680], intron1 [rs737865], and 3′-untranslated region [rs165599]) to predict mothers' reports of inhibitory and attentional control (assessed at 42, 54, 72, and 84 months) and internalizing symptoms (assessed at 24, 30, 42, 48, and 54 months) in a sample of 146 children (79 male). Although the pattern for all three variants was very similar, Val<sup>158</sup>Met explained more variance in both outcomes than did intron1, the 3′-untranslated region, or a haplotype that combined all three catechol-O-methyltransferase variants. In separate models, there were significant three-way interactions among each of the variants, parenting, and sex, predicting the intercepts of inhibitory control and internalizing symptoms. Results suggested that Val<sup>158</sup>Met indexes plasticity, although this effect was moderated by sex. Parenting was positively associated with inhibitory control for methionine-methionine boys and for valine-valine/valine-methionine girls, and was negatively associated with internalizing symptoms for methionine-methionine boys. Using the "regions of significance" technique, genetic differences in inhibitory control were found for children exposed to high-quality parenting, whereas genetic differences in internalizing were found for children exposed to low-quality parenting. These findings provide evidence in support of testing for differential susceptibility across multiple outcomes.

Original languageEnglish (US)
Pages (from-to)709-723
Number of pages15
JournalDevelopment and Psychopathology
Volume27
Issue number3
DOIs
StatePublished - Aug 21 2015

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Catechol O-Methyltransferase
Parenting
Methionine
Genotype
Valine
3' Untranslated Regions
Genetic Techniques
Haplotypes
Mothers
Genes

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

Interactions among catechol-O-methyltransferase genotype, parenting, and sex predict children's internalizing symptoms and inhibitory control : Evidence for differential susceptibility. / Sulik, Michael J.; Eisenberg, Nancy; Spinrad, Tracy; Lemery, Kathryn; Swann, Gregory; Silva, Kassondra M.; Reiser, Mark; Stover, Daryn A.; Verrelli, Brian C.

In: Development and Psychopathology, Vol. 27, No. 3, 21.08.2015, p. 709-723.

Research output: Contribution to journalArticle

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