Interaction of gold nanoglycodendrimers with algal cells (Chlamydomonas reinhardtii) and their effect on physiological processes

Francois Perreault, Nicoleta Bogdan, Mario Morin, Jérme Claverie, Radovan Popovic

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

With the rise of nanotechnologies, the risk of contamination of aquatic ecosystems with nanoparticles is increasing. Glycodendrimer-coated gold nanoparticles have been developed for biomedical applications; however, their effect on microalgae has never been studied. In this report, their interactions with algae were investigated using two strains of Chlamydomonas reinhardtii, a wild type having cell wall and a cell wall-deficient mutant. Cultures were exposed 48 h to 6 and 12 ng ml -1 of gold nanoparticles coated with mannose generation 0 polyamidoamine dendrimer. Culture aggregation was found only for wild type cells, probably because of interactions between mannose and cell wall glycoproteins. Nanoparticles penetrated cytoplasm in both strains; however, inhibition of algal growth and photosynthetic activity was found only in the wild type. We conclude that nanoparticles' deteriorating effect in algae is caused by interactions with the cell wall, causing an aggregation of cell culture, and not by nanoparticle penetration inside the cytoplasm.

Original languageEnglish (US)
Pages (from-to)109-120
Number of pages12
JournalNanotoxicology
Volume6
Issue number2
DOIs
StatePublished - Mar 2012
Externally publishedYes

Fingerprint

Physiological Phenomena
Chlamydomonas reinhardtii
Gold
Nanoparticles
Cell Wall
Cells
Mannose
Algae
Cell culture
Cytoplasm
Agglomeration
Microalgae
Dendrimers
Glycoproteins
Aquatic ecosystems
Nanotechnology
Ecosystem
Contamination
Cell Culture Techniques
Growth

Keywords

  • Algae
  • Cell wall
  • Glycodendrimer
  • Gold nanoparticles
  • Photosynthesis

ASJC Scopus subject areas

  • Biomedical Engineering
  • Toxicology

Cite this

Interaction of gold nanoglycodendrimers with algal cells (Chlamydomonas reinhardtii) and their effect on physiological processes. / Perreault, Francois; Bogdan, Nicoleta; Morin, Mario; Claverie, Jérme; Popovic, Radovan.

In: Nanotoxicology, Vol. 6, No. 2, 03.2012, p. 109-120.

Research output: Contribution to journalArticle

Perreault, Francois ; Bogdan, Nicoleta ; Morin, Mario ; Claverie, Jérme ; Popovic, Radovan. / Interaction of gold nanoglycodendrimers with algal cells (Chlamydomonas reinhardtii) and their effect on physiological processes. In: Nanotoxicology. 2012 ; Vol. 6, No. 2. pp. 109-120.
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