Interaction of bleomycin with DNA

James C. Quada, Guy F. Zuber, Sidney Hecht

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

It has been shown previously that two structural domains of bleomycin mediate the interaction of the antitumor antibiotic with DNA. At least three lines of evidence indicate that the metal binding domain is the predominant partner, and is responsible for the sequence selectivity of DNA cleavage observed for Fe(II)•BLM. The bithiazole + C-terminus has been shown previously to bind to DNA, but not to exhibit any sequence selectivity. Presently, it is shown that the bithiazole + C-terminus may also exhibit sequence selectivity, albeit not in the same fashion as bleomycin itself. The potential of this selectivity to contribute to the recognition of high affinity sites on DNA by bleomycin is discussed.

Original languageEnglish (US)
Pages (from-to)307-311
Number of pages5
JournalPure and Applied Chemistry
Volume70
Issue number2
StatePublished - Feb 1998
Externally publishedYes

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Bleomycin
DNA
Antibiotics
Metals
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Quada, J. C., Zuber, G. F., & Hecht, S. (1998). Interaction of bleomycin with DNA. Pure and Applied Chemistry, 70(2), 307-311.

Interaction of bleomycin with DNA. / Quada, James C.; Zuber, Guy F.; Hecht, Sidney.

In: Pure and Applied Chemistry, Vol. 70, No. 2, 02.1998, p. 307-311.

Research output: Contribution to journalArticle

Quada, JC, Zuber, GF & Hecht, S 1998, 'Interaction of bleomycin with DNA', Pure and Applied Chemistry, vol. 70, no. 2, pp. 307-311.
Quada JC, Zuber GF, Hecht S. Interaction of bleomycin with DNA. Pure and Applied Chemistry. 1998 Feb;70(2):307-311.
Quada, James C. ; Zuber, Guy F. ; Hecht, Sidney. / Interaction of bleomycin with DNA. In: Pure and Applied Chemistry. 1998 ; Vol. 70, No. 2. pp. 307-311.
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