Inter-species normalization of gene mentions with GNAT

Jörg Hakenberg, Conrad Plake, Robert Leaman, Michael Schroeder, Graciela Gonzalez

    Research output: Contribution to journalArticle

    79 Scopus citations

    Abstract

    Motivation: Text mining in the biomedical domain aims at helping researchers to access information contained in scientific publications in a faster, easier and more complete way. One step towards this aim is the recognition of named entities and their subsequent normalization to database identifiers. Normalization helps to link objects of potential interest, such as genes, to detailed information not contained in a publication; it is also key for integrating different knowledge sources. From an information retrieval perspective, normalization facilitates indexing and querying. Gene mention normalization (GN) is particularly challenging given the high ambiguity of gene names: they refer to orthologous or entirely different genes, are named after phenotypes and other biomedical terms, or they resemble common English words. Results: We present the first publicly available system, GNAT, reported to handle inter-species GN. Our method uses extensive background knowledge on genes to resolve ambiguous names to EntrezGene identifiers. It performs comparably to single-species approaches proposed by us and others. On a benchmark set derived from BioCreative 1 and 2 data that contains genes from 13 species, GNAT achieves an F-measure of 81.4% (90.8% precision at 73.8% recall). For the single-species task, we report an F-measure of 85.4% on human genes.

    Original languageEnglish (US)
    Pages (from-to)i126-i132
    JournalBioinformatics
    Volume24
    Issue number16
    DOIs
    StatePublished - Aug 1 2008

    ASJC Scopus subject areas

    • Statistics and Probability
    • Biochemistry
    • Molecular Biology
    • Computer Science Applications
    • Computational Theory and Mathematics
    • Computational Mathematics

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    Hakenberg, J., Plake, C., Leaman, R., Schroeder, M., & Gonzalez, G. (2008). Inter-species normalization of gene mentions with GNAT. Bioinformatics, 24(16), i126-i132. https://doi.org/10.1093/bioinformatics/btn299