Abstract
DNA nanotechnology has emerged as a reliable and programmable way of controlling matter at the nanoscale through the specificity of Watson-Crick base pairing, allowing both complex self-assembled structures with nanometer precision and complex reaction networks implementing digital and analog behaviors. Here we show how two well-developed frameworks, DNA tile self-assembly and DNA strand-displacement circuits, can be systematically integrated to provide programmable kinetic control of self-assembly. We demonstrate the triggered and catalytic isothermal self-assembly of DNA nanotubes over 10 μm long from precursor DNA double-crossover tiles activated by an upstream DNA catalyst network. Integrating more sophisticated control circuits and tile systems could enable precise spatial and temporal organization of dynamic molecular structures.
| Original language | English (US) |
|---|---|
| Article number | 2965 |
| Journal | Nature Communications |
| Volume | 4 |
| DOIs | |
| State | Published - 2013 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Chemistry(all)
- Physics and Astronomy(all)
Cite this
Integrating DNA strand-displacement circuitry with DNA tile self-assembly. / Zhang, David Yu; Hariadi, Rizal; Choi, Harry M T; Winfree, Erik.
In: Nature Communications, Vol. 4, 2965, 2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Integrating DNA strand-displacement circuitry with DNA tile self-assembly
AU - Zhang, David Yu
AU - Hariadi, Rizal
AU - Choi, Harry M T
AU - Winfree, Erik
PY - 2013
Y1 - 2013
N2 - DNA nanotechnology has emerged as a reliable and programmable way of controlling matter at the nanoscale through the specificity of Watson-Crick base pairing, allowing both complex self-assembled structures with nanometer precision and complex reaction networks implementing digital and analog behaviors. Here we show how two well-developed frameworks, DNA tile self-assembly and DNA strand-displacement circuits, can be systematically integrated to provide programmable kinetic control of self-assembly. We demonstrate the triggered and catalytic isothermal self-assembly of DNA nanotubes over 10 μm long from precursor DNA double-crossover tiles activated by an upstream DNA catalyst network. Integrating more sophisticated control circuits and tile systems could enable precise spatial and temporal organization of dynamic molecular structures.
AB - DNA nanotechnology has emerged as a reliable and programmable way of controlling matter at the nanoscale through the specificity of Watson-Crick base pairing, allowing both complex self-assembled structures with nanometer precision and complex reaction networks implementing digital and analog behaviors. Here we show how two well-developed frameworks, DNA tile self-assembly and DNA strand-displacement circuits, can be systematically integrated to provide programmable kinetic control of self-assembly. We demonstrate the triggered and catalytic isothermal self-assembly of DNA nanotubes over 10 μm long from precursor DNA double-crossover tiles activated by an upstream DNA catalyst network. Integrating more sophisticated control circuits and tile systems could enable precise spatial and temporal organization of dynamic molecular structures.
UR - http://www.scopus.com/inward/record.url?scp=84879624827&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879624827&partnerID=8YFLogxK
U2 - 10.1038/ncomms2965
DO - 10.1038/ncomms2965
M3 - Article
C2 - 23756381
AN - SCOPUS:84879624827
VL - 4
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 2965
ER -