Integrated microsystem for classification, sorting, and storage of cellular nuclei based on DNA content from a tissue biopsy

Mark Holl, Thomas Paulson, Brian Rabkin, Erin Gibbons, Turgut Kosar, Deirdre Meldrum

Research output: Contribution to journalArticle

Abstract

The problem of preparing clean DNA derived from clinical samples remains one of the most difficult challenges to reducing laboratory scale distributed processesing systems into integrated micro total analysis systems. This study provides a solid analysis and set of design alternatives to achieve this significant goal. The microsystem design is intended to replace labor intensive procedures requiring highly trained and skilled laboratory personnel. An exploratory design is presented for an integrated, automated microsystem.

Original languageEnglish (US)
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
StatePublished - 2000
Externally publishedYes

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Biopsy
Microsystems
Sorting
DNA
Tissue
Personnel

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Integrated microsystem for classification, sorting, and storage of cellular nuclei based on DNA content from a tissue biopsy. / Holl, Mark; Paulson, Thomas; Rabkin, Brian; Gibbons, Erin; Kosar, Turgut; Meldrum, Deirdre.

In: Annals of Biomedical Engineering, Vol. 28, No. SUPPL. 1, 2000.

Research output: Contribution to journalArticle

Holl, Mark ; Paulson, Thomas ; Rabkin, Brian ; Gibbons, Erin ; Kosar, Turgut ; Meldrum, Deirdre. / Integrated microsystem for classification, sorting, and storage of cellular nuclei based on DNA content from a tissue biopsy. In: Annals of Biomedical Engineering. 2000 ; Vol. 28, No. SUPPL. 1.
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