Integrated human genome-wide maps constructed using the CEPH reference panel

Kenneth Buetow, James L. Weber, Susan Ludwigsen, Titia Scherpbier-Heddema, Geoffrey M. Duyk, Val C. Sheffield, Zhenyuan Wang, Jeffrey C. Murray

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

High resolution linkage maps have proven to be invaluable tools in genetic investigations. We have assembled a collection of genetic maps constructed from primary data collected from investigators performing genotyping using the Centre Etude Polymorphism Humain (CEPH) reference pedigree panel. These maps were constructed using a rigorous, semi-automated map construction algorithm that evaluates the integrity of the maps during construction. Two classes of maps were produced: a high confidence 'skeletal' set composed of 544 PCR based markers, and a more highly annotated 'framework' set containing maps of 1,123 markers. Genetic map locations within the framework maps are provided for an additional 1,758 loci without statistically unique interval assignments.

Original languageEnglish (US)
Pages (from-to)391-393
Number of pages3
JournalNature Genetics
Volume6
Issue number4
DOIs
StatePublished - Apr 1994
Externally publishedYes

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Human Genome
Pedigree
Research Personnel
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Buetow, K., Weber, J. L., Ludwigsen, S., Scherpbier-Heddema, T., Duyk, G. M., Sheffield, V. C., ... Murray, J. C. (1994). Integrated human genome-wide maps constructed using the CEPH reference panel. Nature Genetics, 6(4), 391-393. https://doi.org/10.1038/ng0494-391

Integrated human genome-wide maps constructed using the CEPH reference panel. / Buetow, Kenneth; Weber, James L.; Ludwigsen, Susan; Scherpbier-Heddema, Titia; Duyk, Geoffrey M.; Sheffield, Val C.; Wang, Zhenyuan; Murray, Jeffrey C.

In: Nature Genetics, Vol. 6, No. 4, 04.1994, p. 391-393.

Research output: Contribution to journalArticle

Buetow, K, Weber, JL, Ludwigsen, S, Scherpbier-Heddema, T, Duyk, GM, Sheffield, VC, Wang, Z & Murray, JC 1994, 'Integrated human genome-wide maps constructed using the CEPH reference panel', Nature Genetics, vol. 6, no. 4, pp. 391-393. https://doi.org/10.1038/ng0494-391
Buetow K, Weber JL, Ludwigsen S, Scherpbier-Heddema T, Duyk GM, Sheffield VC et al. Integrated human genome-wide maps constructed using the CEPH reference panel. Nature Genetics. 1994 Apr;6(4):391-393. https://doi.org/10.1038/ng0494-391
Buetow, Kenneth ; Weber, James L. ; Ludwigsen, Susan ; Scherpbier-Heddema, Titia ; Duyk, Geoffrey M. ; Sheffield, Val C. ; Wang, Zhenyuan ; Murray, Jeffrey C. / Integrated human genome-wide maps constructed using the CEPH reference panel. In: Nature Genetics. 1994 ; Vol. 6, No. 4. pp. 391-393.
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