Insulin sensitivity, insulin secretion and β-cell function during puberty in overweight Hispanic children with a family history of type 2 diabetes

G. D.C. Ball, M. J. Weigensberg, M. L. Cruz, G. Q. Shaibi, H. A. Kobaissi, M. I. Goran

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

OBJECTIVE: To examine cross-sectional differences in insulin sensitivity, insulin secretion and β-cell function during puberty in overweight Hispanic boys and girls with a family history of type 2 diabetes. STUDY DESIGN AND PARTICIPANTS: This cross-sectional, observational study included 214 8-13-y-old Hispanic children with a BMI percentile ≥85th percentile and family history of type 2 diabetes. METHODS AND ANALYSES: Participants underwent a physical examination, body composition measures, oral glucose tolerance test (OGTT), and frequently-sampled intravenous glucose tolerance test. Unadjusted and adjusted general linear models (GLM) tested whether insulin/glucose dynamics differed by Tanner stage and gender. RESULTS: Unadjusted group comparisons showed that fasting insulin increased whereas insulin sensitivity (SI) and the disposition index (DI) (a measure of pancreatic β-cell function) decreased across Tanner stage groups (all P<0.05). No differences in the acute insulin response to glucose (AIRg), fasting glucose or 2-h glucose were found. After adjusting for covariates, there was no independent effect of Tanner stage on SI (P=0.9) or AIRg (P=0.2), but DI was slightly lower in later Tanner stages suggesting decreased β-cell function in the more mature groups (P=0.10). CONCLUSIONS: Overweight Hispanic children with a family history of type 2 diabetes may represent a unique population given that pubertal insulin resistance was not evident once analyses controlled for body composition. Longitudinal analyses are required to determine whether the slightly diminished β-cell function in later Tanner stages plays a role in the development of type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)1471-1477
Number of pages7
JournalInternational Journal of Obesity
Volume29
Issue number12
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

Keywords

  • Insulin resistance
  • Latino
  • Tanner stage
  • Youth

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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