Inhibition of a chicken B-cell lymphoma by suppressor T-cells from agammaglobulinemic chickens

D. S. Chi, J. M. Sharma

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The growth of B-cell lymphoma, LSCC-RP9, in culture was inhibited by spleen cells from bursa-immunized agammaglobulinemic (A-gamma) chickens. This inhibition was mediated by suppressor T-cells. The growth of transplantable LSCT-RP6 B-cell lymphoma was suppressed in A-gamma chickens, while that of the control SPCT-RP11 T-cell tumor was not affected. Furthermore, the incidence and growth of the LSCT-RP6 tumor in normal recipients were decreased when it was co-transplanted with spleen cells from bursa immunized A-gamma chickens. The results suggest that suppressor T-cells inhibit the growth of B-cell lymphoma.

Original languageEnglish (US)
Pages (from-to)1347-1352
Number of pages6
JournalAnticancer Research
Volume10
Issue number5 A
StatePublished - Jan 1 1990

Keywords

  • B-cell
  • agammaglobulinemia
  • chicken
  • lymphoma growth
  • suppressor T-cell

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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