Ingestive behaviour of the pigeon: Stereoselective influence of the opiate agonist levorphanol and its antagonism by naloxone

P. Deviche, G. Schepers

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Four experiments evaluated the effect of levorphanol on ingestive behaviour of different groups of non-deprived pigeons. In experiments 1 and 2, levorphanol and its (+)stereoisomer dextrorphan were administered at three doses (0.25, 1 and 2 mg). As compared with control values, levorphanol dose-dependently reduced food intake. This anorexia persisted for at least 5 h post-injection. A late hyperdipsia was also observed. These changes were stereoselective, suggesting that they followed the binding of levorphanol to opiate receptors. In experiments 3 and 4, the anorexic effect of 1 mg levorphanol, but not its hyperdipsic effect, was partly antagonized by the concomitant administration of either 0.25 mg or 1 mg naloxone. Given alone at the dose of 1 mg, naloxone slightly and transiently reduced food, but not water, intake. These results are discussed in terms of the endorphinergic regulation of ingestive behaviour in birds.

Original languageEnglish (US)
Pages (from-to)357-362
Number of pages6
JournalPsychopharmacology
Volume83
Issue number4
DOIs
StatePublished - Dec 1 1984
Externally publishedYes

Keywords

  • Drinking
  • Feeding
  • Levorphanol
  • Naloxone
  • Opiates
  • Pigeon
  • Stereoselectivity

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Ingestive behaviour of the pigeon: Stereoselective influence of the opiate agonist levorphanol and its antagonism by naloxone'. Together they form a unique fingerprint.

Cite this