Abstract

Embolic coiling is the most popular endovascular treatment available for cerebral aneurysms. Nevertheless, the embolic coiling of wide-neck aneurysms is challenging and, in many cases, ineffective. Use of highly porous stents to support coiling of wide-neck aneurysms has become a common procedure in recent years. Several studies have also demonstrated that high porosity stents alone can significantly alter aneurysmal hemodynamics, but differences among different stent configurations have not been fully characterized. As a result, it is usually unclear which stent configuration is optimal for treatment. In this paper, we present a flow study that elucidates the influence of stent configuration on cerebral aneurysm fluid dynamics in an idealized wide-neck basilar tip aneurysm model. Aneurysmal fluid dynamics for three different stent configurations (half-Y, Y and, cross-bar) were first quantified using particle image velocimetry and then compared. Computational fluid dynamics (CFD) simulations were also conducted for selected stent configurations to facilitate validation and provide more detailed characterizations of the fluid dynamics promoted by different stent configurations. In vitro results showed that the Y stent configuration reduced cross-neck flow most significantly, while the cross-bar configuration reduced velocity magnitudes within the aneurysmal sac most significantly. The half-Y configuration led to increased velocity magnitudes within the aneurysmal sac at high parent-vessel flow rates. Experimental results were in strong agreement with CFD simulations. Simulated results indicated that differences in fluid dynamic performance among the different stent configurations can be attributed primarily to protruding struts within the bifurcation region.

Original languageEnglish (US)
Pages (from-to)440-447
Number of pages8
JournalJournal of Biomechanics
Volume45
Issue number3
DOIs
StatePublished - Feb 2 2012

Fingerprint

Stents
Intracranial Aneurysm
Hydrodynamics
Fluid dynamics
Neck
Aneurysm
Computational fluid dynamics
Rheology
Struts
Porosity
Computer simulation
Hemodynamics
Velocity measurement
Flow rate

Keywords

  • Cerebral aneurysms
  • CFD
  • Endovascular stents
  • PIV
  • Stent configuration

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Rehabilitation
  • Biophysics
  • Biomedical Engineering

Cite this

Influence of stent configuration on cerebral aneurysm fluid dynamics. / Babiker, M. Haithem; Gonzalez, L. Fernando; Ryan, Justin; Albuquerque, Felipe; Collins, Daniel; Elvikis, Arius; Frakes, David.

In: Journal of Biomechanics, Vol. 45, No. 3, 02.02.2012, p. 440-447.

Research output: Contribution to journalArticle

Babiker, M. Haithem ; Gonzalez, L. Fernando ; Ryan, Justin ; Albuquerque, Felipe ; Collins, Daniel ; Elvikis, Arius ; Frakes, David. / Influence of stent configuration on cerebral aneurysm fluid dynamics. In: Journal of Biomechanics. 2012 ; Vol. 45, No. 3. pp. 440-447.
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