Influence of lipids on protein-mediated transmembrane transport

Elizabeth J. Denning, Oliver Beckstein

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Transmembrane proteins are responsible for transporting ions and small molecules across the hydrophobic region of the cell membrane. We are reviewing the evidence for regulation of these transport processes by interactions with the lipids of the membrane. We focus on ion channels, including potassium channels, mechanosensitive and pentameric ligand gated ion channels, and active transporters, including pumps, sodium or proton driven secondary transporters and ABC transporters. For ion channels it has been convincingly shown that specific lipid-protein interactions can directly affect their function. In some cases, a combined approach of molecular and structural biology together with computer simulations has revealed the molecular mechanisms. There are also many transporters whose activity depends on lipids but understanding of the molecular mechanisms is only beginning.

Original languageEnglish (US)
Pages (from-to)57-71
Number of pages15
JournalChemistry and Physics of Lipids
Volume169
DOIs
StatePublished - Apr 2013

Fingerprint

Protein Transport
Ion Channels
Ligand-Gated Ion Channels
Lipids
Proton Pumps
Sodium-Potassium-Exchanging ATPase
ATP-Binding Cassette Transporters
Potassium Channels
Cell membranes
Membrane Lipids
Computer Simulation
Molecular Biology
Proteins
Cell Membrane
Ions
Molecules
Computer simulation

Keywords

  • Ion channel
  • Membrane
  • Transporter

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Cell Biology

Cite this

Influence of lipids on protein-mediated transmembrane transport. / Denning, Elizabeth J.; Beckstein, Oliver.

In: Chemistry and Physics of Lipids, Vol. 169, 04.2013, p. 57-71.

Research output: Contribution to journalArticle

@article{82170fccf82c4fba880bfccdb72e138d,
title = "Influence of lipids on protein-mediated transmembrane transport",
abstract = "Transmembrane proteins are responsible for transporting ions and small molecules across the hydrophobic region of the cell membrane. We are reviewing the evidence for regulation of these transport processes by interactions with the lipids of the membrane. We focus on ion channels, including potassium channels, mechanosensitive and pentameric ligand gated ion channels, and active transporters, including pumps, sodium or proton driven secondary transporters and ABC transporters. For ion channels it has been convincingly shown that specific lipid-protein interactions can directly affect their function. In some cases, a combined approach of molecular and structural biology together with computer simulations has revealed the molecular mechanisms. There are also many transporters whose activity depends on lipids but understanding of the molecular mechanisms is only beginning.",
keywords = "Ion channel, Membrane, Transporter",
author = "Denning, {Elizabeth J.} and Oliver Beckstein",
year = "2013",
month = "4",
doi = "10.1016/j.chemphyslip.2013.02.007",
language = "English (US)",
volume = "169",
pages = "57--71",
journal = "Chemistry and Physics of Lipids",
issn = "0009-3084",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Influence of lipids on protein-mediated transmembrane transport

AU - Denning, Elizabeth J.

AU - Beckstein, Oliver

PY - 2013/4

Y1 - 2013/4

N2 - Transmembrane proteins are responsible for transporting ions and small molecules across the hydrophobic region of the cell membrane. We are reviewing the evidence for regulation of these transport processes by interactions with the lipids of the membrane. We focus on ion channels, including potassium channels, mechanosensitive and pentameric ligand gated ion channels, and active transporters, including pumps, sodium or proton driven secondary transporters and ABC transporters. For ion channels it has been convincingly shown that specific lipid-protein interactions can directly affect their function. In some cases, a combined approach of molecular and structural biology together with computer simulations has revealed the molecular mechanisms. There are also many transporters whose activity depends on lipids but understanding of the molecular mechanisms is only beginning.

AB - Transmembrane proteins are responsible for transporting ions and small molecules across the hydrophobic region of the cell membrane. We are reviewing the evidence for regulation of these transport processes by interactions with the lipids of the membrane. We focus on ion channels, including potassium channels, mechanosensitive and pentameric ligand gated ion channels, and active transporters, including pumps, sodium or proton driven secondary transporters and ABC transporters. For ion channels it has been convincingly shown that specific lipid-protein interactions can directly affect their function. In some cases, a combined approach of molecular and structural biology together with computer simulations has revealed the molecular mechanisms. There are also many transporters whose activity depends on lipids but understanding of the molecular mechanisms is only beginning.

KW - Ion channel

KW - Membrane

KW - Transporter

UR - http://www.scopus.com/inward/record.url?scp=84876406310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876406310&partnerID=8YFLogxK

U2 - 10.1016/j.chemphyslip.2013.02.007

DO - 10.1016/j.chemphyslip.2013.02.007

M3 - Article

C2 - 23473882

AN - SCOPUS:84876406310

VL - 169

SP - 57

EP - 71

JO - Chemistry and Physics of Lipids

JF - Chemistry and Physics of Lipids

SN - 0009-3084

ER -