TY - JOUR
T1 - Influence of lipids on protein-mediated transmembrane transport
AU - Denning, Elizabeth J.
AU - Beckstein, Oliver
PY - 2013/4
Y1 - 2013/4
N2 - Transmembrane proteins are responsible for transporting ions and small molecules across the hydrophobic region of the cell membrane. We are reviewing the evidence for regulation of these transport processes by interactions with the lipids of the membrane. We focus on ion channels, including potassium channels, mechanosensitive and pentameric ligand gated ion channels, and active transporters, including pumps, sodium or proton driven secondary transporters and ABC transporters. For ion channels it has been convincingly shown that specific lipid-protein interactions can directly affect their function. In some cases, a combined approach of molecular and structural biology together with computer simulations has revealed the molecular mechanisms. There are also many transporters whose activity depends on lipids but understanding of the molecular mechanisms is only beginning.
AB - Transmembrane proteins are responsible for transporting ions and small molecules across the hydrophobic region of the cell membrane. We are reviewing the evidence for regulation of these transport processes by interactions with the lipids of the membrane. We focus on ion channels, including potassium channels, mechanosensitive and pentameric ligand gated ion channels, and active transporters, including pumps, sodium or proton driven secondary transporters and ABC transporters. For ion channels it has been convincingly shown that specific lipid-protein interactions can directly affect their function. In some cases, a combined approach of molecular and structural biology together with computer simulations has revealed the molecular mechanisms. There are also many transporters whose activity depends on lipids but understanding of the molecular mechanisms is only beginning.
KW - Ion channel
KW - Membrane
KW - Transporter
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U2 - 10.1016/j.chemphyslip.2013.02.007
DO - 10.1016/j.chemphyslip.2013.02.007
M3 - Article
C2 - 23473882
AN - SCOPUS:84876406310
SN - 0009-3084
VL - 169
SP - 57
EP - 71
JO - Chemistry and Physics of Lipids
JF - Chemistry and Physics of Lipids
ER -