Influence of breastfeeding on obesity and type 2 diabetes risk factors in latino youth with a family history of type 2 diabetes

Jaimie N. Davis, Marc J. Weigensberg, Gabriel Shaibi, Noe C. Crespo, Louise A. Kelly, Christianne J. Lane, Michael I. Goran

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

OBJECTIVE - To determine whether breastfeeding is related to total adiposity, regional adiposity, and glucose and insulin dynamics in overweight Latino youth throughout puberty. RESEARCH DESIGN AND METHODS - The relation between breastfeeding and diabetes risk was determined in 240 overweight (BMI ≥85th percentile) Latino children (aged 8-13 years) with a positive family history of type 2 diabetes. Children were examined at baseline (Tanner pubertal stage 1) and for 2 more years as they advanced in pubertal maturation. Children were divided into the following categories: never breastfed (n = 102), breastfed 0-5.99 months (n = 61), breastfed 6-11.99 months (n = 24), and breastfed ≥12 months (n = 53). Tanner pubertal stage was determined by physical examination. Visceral and subcutaneous abdominal fat were determined by magnetic resonance imagining, and total body fat, total lean tissue mass, and percent body fat were measured by dual-energy X-ray absorptiometry. Fasting and post-challenge glucose were assessed with a 2-h oral glucose tolerance test. Insulin sensitivity (SI), acute insulin response (AIR), and disposition index ([DI] an index of β-cell function) were measured by frequently sampled intravenous glucose tolerance test and minimal modeling. Data were analyzed using linear mixed-effects modeling. RESULTS - There were no significant effects of breastfeeding categories on adiposity (i.e., total fat mass, total lean tissue mass, percent body fat), fat distribution (visceral and subcutaneous abdominal fat), fasting glucose or 2-h glucose, or insulin dynamics (SI, AIR, and DI) at Tanner pubertal stage 1 or on changes in these variables over pubertal transitions in overweight Latino youth. CONCLUSIONS - In this population of high-risk Latino youth, there were no significant protective effects of breastfeeding on adiposity or type 2 diabetes risk factors at Tanner pubertal stage 1 or across advances in maturation.

Original languageEnglish (US)
Pages (from-to)784-789
Number of pages6
JournalDiabetes Care
Volume30
Issue number4
DOIs
StatePublished - Apr 2007

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Adiposity
Breast Feeding
Hispanic Americans
Type 2 Diabetes Mellitus
Obesity
Abdominal Subcutaneous Fat
Adipose Tissue
Glucose
Intra-Abdominal Fat
Insulin
Glucose Tolerance Test
Insulin Resistance
Fasting
Photon Absorptiometry
Puberty
Physical Examination
Research Design
Magnetic Resonance Spectroscopy
Fats
Population

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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Influence of breastfeeding on obesity and type 2 diabetes risk factors in latino youth with a family history of type 2 diabetes. / Davis, Jaimie N.; Weigensberg, Marc J.; Shaibi, Gabriel; Crespo, Noe C.; Kelly, Louise A.; Lane, Christianne J.; Goran, Michael I.

In: Diabetes Care, Vol. 30, No. 4, 04.2007, p. 784-789.

Research output: Contribution to journalArticle

Davis, Jaimie N. ; Weigensberg, Marc J. ; Shaibi, Gabriel ; Crespo, Noe C. ; Kelly, Louise A. ; Lane, Christianne J. ; Goran, Michael I. / Influence of breastfeeding on obesity and type 2 diabetes risk factors in latino youth with a family history of type 2 diabetes. In: Diabetes Care. 2007 ; Vol. 30, No. 4. pp. 784-789.
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abstract = "OBJECTIVE - To determine whether breastfeeding is related to total adiposity, regional adiposity, and glucose and insulin dynamics in overweight Latino youth throughout puberty. RESEARCH DESIGN AND METHODS - The relation between breastfeeding and diabetes risk was determined in 240 overweight (BMI ≥85th percentile) Latino children (aged 8-13 years) with a positive family history of type 2 diabetes. Children were examined at baseline (Tanner pubertal stage 1) and for 2 more years as they advanced in pubertal maturation. Children were divided into the following categories: never breastfed (n = 102), breastfed 0-5.99 months (n = 61), breastfed 6-11.99 months (n = 24), and breastfed ≥12 months (n = 53). Tanner pubertal stage was determined by physical examination. Visceral and subcutaneous abdominal fat were determined by magnetic resonance imagining, and total body fat, total lean tissue mass, and percent body fat were measured by dual-energy X-ray absorptiometry. Fasting and post-challenge glucose were assessed with a 2-h oral glucose tolerance test. Insulin sensitivity (SI), acute insulin response (AIR), and disposition index ([DI] an index of β-cell function) were measured by frequently sampled intravenous glucose tolerance test and minimal modeling. Data were analyzed using linear mixed-effects modeling. RESULTS - There were no significant effects of breastfeeding categories on adiposity (i.e., total fat mass, total lean tissue mass, percent body fat), fat distribution (visceral and subcutaneous abdominal fat), fasting glucose or 2-h glucose, or insulin dynamics (SI, AIR, and DI) at Tanner pubertal stage 1 or on changes in these variables over pubertal transitions in overweight Latino youth. CONCLUSIONS - In this population of high-risk Latino youth, there were no significant protective effects of breastfeeding on adiposity or type 2 diabetes risk factors at Tanner pubertal stage 1 or across advances in maturation.",
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