Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults

Todd A. Trappe, Chad C. Carroll, Jared Dickinson, Jennifer K. LeMoine, Jacob M. Haus, Bridget E. Sullivan, Jonah D. Lee, Bozena Jemiolo, Eileen M. Weinheimer, Chris J. Hollon

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Evidence suggests that consumption of over-the-counter cyclooxygenase (COX) inhibitors may interfere with the positive effects that resistance exercise training has on reversing sarcopenia in older adults. This study examined the influence of acetaminophen or ibuprofen consumption on muscle mass and strength during 12 wk of knee extensor progressive resistance exercise training in older adults. Thirty-six individuals were randomly assigned to one of three groups and consumed the COX-inhibiting drugs in double-blind placebo-controlled fashion: placebo (67 ± 2 yr; n = 12), acetaminophen (64 ± 1 yr; n = 11; 4 g/day), and ibuprofen (64 ± 1 yr; n = 13; 1.2 g/day). Compliance with the resistance training program (100%) and drug consumption (via digital video observation, 94%), and resistance training intensity were similar (P > 0.05) for all three groups. Drug consumption unexpectedly increased muscle volume (acetaminophen: 109 ± 14 cm3, 12.5%; ibuprofen: 84 ± 10 cm3, 10.9%) and muscle strength (acetaminophen: 19 ± 2 kg; ibuprofen: 19 ± 2 kg) to a greater extent (P < 0.05) than placebo (muscle volume: 69 ± 12 cm3, 8.6%; muscle strength: 15 ± 2 kg), when controlling for initial muscle size and strength. Follow-up analysis of muscle biopsies taken from the vastus lateralis before and after training showed muscle protein content, muscle water content, and myosin heavy chain distribution were not influenced (P > 0.05) by drug consumption. Similarly, muscle content of the two known enzymes potentially targeted by the drugs, COX-1 and -2, was not influenced (P > 0.05) by drug consumption, although resistance training did result in a drug-independent increase in COX-1 (32 ± 8%; P < 0.05). Drug consumption did not influence the size of the nonresistance-trained hamstring muscles (P > 0.05). Over-thecounter doses of acetaminophen or ibuprofen, when consumed in combination with resistance training, do not inhibit and appear to enhance muscle hypertrophy and strength gains in older adults. The present findings coupled with previous short-term exercise studies provide convincing evidence that the COX pathway(s) are involved in the regulation of muscle protein turnover and muscle mass in humans.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume300
Issue number3
DOIs
StatePublished - Mar 2011
Externally publishedYes

Fingerprint

Ibuprofen
Acetaminophen
Resistance Training
Skeletal Muscle
Pharmaceutical Preparations
Muscle Strength
Cyclooxygenase 1
Prostaglandin-Endoperoxide Synthases
Muscles
Placebos
Exercise
Sarcopenia
Cyclooxygenase Inhibitors
Muscle Proteins
Cyclooxygenase 2
Hypertrophy
Knee
Observation
Education
Enzymes

Keywords

  • Cyclooxygenase
  • Prostaglandin
  • Sarcopenia

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults. / Trappe, Todd A.; Carroll, Chad C.; Dickinson, Jared; LeMoine, Jennifer K.; Haus, Jacob M.; Sullivan, Bridget E.; Lee, Jonah D.; Jemiolo, Bozena; Weinheimer, Eileen M.; Hollon, Chris J.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 300, No. 3, 03.2011.

Research output: Contribution to journalArticle

Trappe, Todd A. ; Carroll, Chad C. ; Dickinson, Jared ; LeMoine, Jennifer K. ; Haus, Jacob M. ; Sullivan, Bridget E. ; Lee, Jonah D. ; Jemiolo, Bozena ; Weinheimer, Eileen M. ; Hollon, Chris J. / Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2011 ; Vol. 300, No. 3.
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abstract = "Evidence suggests that consumption of over-the-counter cyclooxygenase (COX) inhibitors may interfere with the positive effects that resistance exercise training has on reversing sarcopenia in older adults. This study examined the influence of acetaminophen or ibuprofen consumption on muscle mass and strength during 12 wk of knee extensor progressive resistance exercise training in older adults. Thirty-six individuals were randomly assigned to one of three groups and consumed the COX-inhibiting drugs in double-blind placebo-controlled fashion: placebo (67 ± 2 yr; n = 12), acetaminophen (64 ± 1 yr; n = 11; 4 g/day), and ibuprofen (64 ± 1 yr; n = 13; 1.2 g/day). Compliance with the resistance training program (100{\%}) and drug consumption (via digital video observation, 94{\%}), and resistance training intensity were similar (P > 0.05) for all three groups. Drug consumption unexpectedly increased muscle volume (acetaminophen: 109 ± 14 cm3, 12.5{\%}; ibuprofen: 84 ± 10 cm3, 10.9{\%}) and muscle strength (acetaminophen: 19 ± 2 kg; ibuprofen: 19 ± 2 kg) to a greater extent (P < 0.05) than placebo (muscle volume: 69 ± 12 cm3, 8.6{\%}; muscle strength: 15 ± 2 kg), when controlling for initial muscle size and strength. Follow-up analysis of muscle biopsies taken from the vastus lateralis before and after training showed muscle protein content, muscle water content, and myosin heavy chain distribution were not influenced (P > 0.05) by drug consumption. Similarly, muscle content of the two known enzymes potentially targeted by the drugs, COX-1 and -2, was not influenced (P > 0.05) by drug consumption, although resistance training did result in a drug-independent increase in COX-1 (32 ± 8{\%}; P < 0.05). Drug consumption did not influence the size of the nonresistance-trained hamstring muscles (P > 0.05). Over-thecounter doses of acetaminophen or ibuprofen, when consumed in combination with resistance training, do not inhibit and appear to enhance muscle hypertrophy and strength gains in older adults. The present findings coupled with previous short-term exercise studies provide convincing evidence that the COX pathway(s) are involved in the regulation of muscle protein turnover and muscle mass in humans.",
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