Inflammatory markers in acute myocardial infarction patients: Preliminary evidence of a prospective association with depressive symptoms

Eric B. Hekler, Jason Rubenstein, Elliot J. Coups, Suzanne Gilligan, Alexander W. Kusnecov, Richard J. Contrada, Matthew J. Steiner, Alan K. Tannenbaum, Elaine A. Leventhal, Tyrone J. Krause

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Inflammatory activity has been associated with both coronary disease and depressive symptoms. We sought to determine whether inflammatory markers in myocardial infarction (MI) patients are prospectively associated with depressive symptomatology. Participants were a convenience sample of MI patients. Depressive symptoms were assessed soon after the MI and again 7 months postdischarge. Inflammatory markers examined were interleukin-6 (IL-6) and interleukin-1β. Results suggest no significant cross-sectional association between inflammatory markers and depressive symptoms at baseline. However, bivariate and multiple regression analyses revealed a significant positive prospective association between baseline IL-6 and depressive symptoms 7 months later (β =.57, p <.01). The results suggest that temporal considerations are important in understanding relationships between inflammation and depressive symptoms following MI.

Original languageEnglish (US)
Pages (from-to)65-81
Number of pages17
JournalJournal of Applied Biobehavioral Research
Volume12
Issue number2
DOIs
StatePublished - Apr 1 2007

ASJC Scopus subject areas

  • Cultural Studies
  • Experimental and Cognitive Psychology
  • Clinical Psychology
  • Social Sciences (miscellaneous)

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