Inflammation in Experimental Models of α-Synucleinopathies

Ashley S. Harms, Jeffrey H. Kordower, Alessandro Sette, Cecilia S. Lindestam Arlehamn, David Sulzer, Robert H. Mach

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Neuroinflammation has long been associated with central nervous system pathology in α-synucleinopathy disorders including Parkinson's disease and multiple system atrophy. In the past decade, research-focused efforts in preclinical and experimental models have rallied around this idea, and considerable effort has been made to delineate critical neuroinflammatory processes. In this article, we discuss challenges in preclinical research, notably the use of animal models to recapitulate and dissect disease phenotypes as well as the need for more sensitive, reliable radiotracers to detect on-target efficacy of immunomodulatory treatments in both human Parkinson's disease as well as preclinical models.

Original languageEnglish (US)
Pages (from-to)37-49
Number of pages13
JournalMovement Disorders
Volume36
Issue number1
DOIs
StatePublished - Jan 2021
Externally publishedYes

Keywords

  • Parkinson's disease; multiple system atrophy; neuroinflammation; alpha-synuclein; T cells; microglia; neurotoxins; antigen; radiotracer; positron emission tomography

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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