Inference of recombinational hotspots using gametic disequilibrium values

Philip W. Hedrick

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Gametic disequilibrium between RFLP sites have been used to infer recombinational hotspots. However, some measures of gametic disequilibrium, such as the correlation coefficient, are quite dependent upon allelic frequencies. The normalized disequilibrium measure of Lewontin, on the other hand, is independent of allelic frequencies. Data from the β-globin gene cluster are used as an illustration of such potential misinterpretations and the use of these measures.

Original languageEnglish (US)
Pages (from-to)435-438
Number of pages4
Issue number3
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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