Inference of recombinational hotspots using gametic disequilibrium values

Philip W. Hedrick

doi:10.1038/hdy.1988.61

Inference of recombinational hotspots using gametic disequilibrium values

Philip W. Hedrick

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Gametic disequilibrium between RFLP sites have been used to infer recombinational hotspots. However, some measures of gametic disequilibrium, such as the correlation coefficient, are quite dependent upon allelic frequencies. The normalized disequilibrium measure of Lewontin, on the other hand, is independent of allelic frequencies. Data from the β-globin gene cluster are used as an illustration of such potential misinterpretations and the use of these measures.

Original language	English (US)
Pages (from-to)	435-438
Number of pages	4
Journal	Heredity
Volume	60
Issue number	3
DOIs	https://doi.org/10.1038/hdy.1988.61
State	Published - Jun 1988
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1038/hdy.1988.61

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title = "Inference of recombinational hotspots using gametic disequilibrium values",

abstract = "Gametic disequilibrium between RFLP sites have been used to infer recombinational hotspots. However, some measures of gametic disequilibrium, such as the correlation coefficient, are quite dependent upon allelic frequencies. The normalized disequilibrium measure of Lewontin, on the other hand, is independent of allelic frequencies. Data from the β-globin gene cluster are used as an illustration of such potential misinterpretations and the use of these measures.",

author = "Hedrick, {Philip W.}",

note = "Funding Information: Acknowledgement This work was supported by NIH grants GM 35326 and HD 12731.",

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N2 - Gametic disequilibrium between RFLP sites have been used to infer recombinational hotspots. However, some measures of gametic disequilibrium, such as the correlation coefficient, are quite dependent upon allelic frequencies. The normalized disequilibrium measure of Lewontin, on the other hand, is independent of allelic frequencies. Data from the β-globin gene cluster are used as an illustration of such potential misinterpretations and the use of these measures.

AB - Gametic disequilibrium between RFLP sites have been used to infer recombinational hotspots. However, some measures of gametic disequilibrium, such as the correlation coefficient, are quite dependent upon allelic frequencies. The normalized disequilibrium measure of Lewontin, on the other hand, is independent of allelic frequencies. Data from the β-globin gene cluster are used as an illustration of such potential misinterpretations and the use of these measures.

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Inference of recombinational hotspots using gametic disequilibrium values

Abstract

ASJC Scopus subject areas

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