TY - JOUR
T1 - Individual differences in early adolescents’ latent trait cortisol
T2 - Interaction of early adversity and 5-HTTLPR
AU - Chen, Frances R.
AU - Stroud, Catherine B.
AU - Vrshek-Schallhorn, Suzanne
AU - Doane, Leah
AU - Granger, Douglas A.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - The present study aimed to examine the interaction of 5-HTTLPR and early adversity on trait-like levels of cortisol. A community sample of 117 early adolescent girls (M age = 12.39 years) provided DNA samples for 5-HTTLPR genotyping, and saliva samples for assessing cortisol 3 times a day (waking, 30 min post-waking, and bedtime) over a three-day period. Latent trait cortisol (LTC) was modeled using the first 2 samples of each day. Early adversity was assessed with objective contextual stress interviews with adolescents and their mothers. A significant 5-HTTLPR × early adversity interaction indicated that greater early adversity was associated with lower LTC levels, but only among individuals with either L/L or S/L genotype. Findings suggest that serotonergic genetic variation may influence the impact of early adversity on individual differences in HPA-axis regulation. Future research should explore whether this interaction contributes to the development of psychopathology through HPA axis functioning.
AB - The present study aimed to examine the interaction of 5-HTTLPR and early adversity on trait-like levels of cortisol. A community sample of 117 early adolescent girls (M age = 12.39 years) provided DNA samples for 5-HTTLPR genotyping, and saliva samples for assessing cortisol 3 times a day (waking, 30 min post-waking, and bedtime) over a three-day period. Latent trait cortisol (LTC) was modeled using the first 2 samples of each day. Early adversity was assessed with objective contextual stress interviews with adolescents and their mothers. A significant 5-HTTLPR × early adversity interaction indicated that greater early adversity was associated with lower LTC levels, but only among individuals with either L/L or S/L genotype. Findings suggest that serotonergic genetic variation may influence the impact of early adversity on individual differences in HPA-axis regulation. Future research should explore whether this interaction contributes to the development of psychopathology through HPA axis functioning.
KW - 5-HTTLPR
KW - Adolescence
KW - Early adversity
KW - Latent trait cortisol
KW - Salivary cortisol
UR - http://www.scopus.com/inward/record.url?scp=85026886050&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85026886050&partnerID=8YFLogxK
U2 - 10.1016/j.biopsycho.2017.07.017
DO - 10.1016/j.biopsycho.2017.07.017
M3 - Article
C2 - 28757071
AN - SCOPUS:85026886050
SN - 0301-0511
VL - 129
SP - 8
EP - 15
JO - Biological Psychology
JF - Biological Psychology
ER -