Increased furan tolerance in Escherichia coli due to a Cryptic ucpA Gene

Xuan Wang, Elliot N. Miller, Lorraine P. Yomano, K. T. Shanmugam, Lonnie O. Ingram

Research output: Contribution to journalComment/debate

20 Scopus citations

Abstract

Expression arrays were used to identify 4 putative oxidoreductases that were upregulated (>3-fold) by furfural (15 mM, 15 min). Plasmid expression of one (ucpA) increased furan tolerance in ethanologenic strain LY180 and wild-type strain W. Deleting ucpA decreased furfural tolerance. Although the mechanism remains unknown, the cryptic ucpA gene is now associated with a phenotype: furan resistance.

Original languageEnglish (US)
Pages (from-to)2452-2455
Number of pages4
JournalApplied and environmental microbiology
Volume78
Issue number7
DOIs
StatePublished - Apr 2012

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology
  • Ecology

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