Increased aneuploidy in Alzheimer disease

B. E. Ward, Robert Cook-Deegan, A. Robinson, J. H. Austin

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The purpose of this study was to determine if cytogenetic changes are present in Alzheimer disease, one of the presenile dementias. The chromosomes of three groups of people were studied: 1) sporadic cases of Alzheimer disease (8 cases), 2) familial cases of Alzheimer disease with affected individuals in at least two generations of their families (5 cases), and 3) currently unaffected siblings of the affected individuals in these families (9 cases). One hundred cells per individual were examined using GTG banding to allow chromosome identification. A statistically significant increase in aneuploidy was found in five of eight patients in group 1 (P < 0.05) and in each of five patients in group 2 (P < 0.001) when compared with the rate of aneuploidy in age- and sex-matched controls. In addition, two individuals in group 3 exhibited a significant increase in aneuploidy over the control group, raising the possibility that finding increased aneuploidy may allow one to anticipate the clinical expression of the disease state.

Original languageEnglish (US)
Pages (from-to)137-144
Number of pages8
JournalAmerican Journal of Medical Genetics
Volume3
Issue number2
StatePublished - 1979
Externally publishedYes

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Aneuploidy
Alzheimer Disease
Chromosomes
Cytogenetics
Siblings
Control Groups

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Ward, B. E., Cook-Deegan, R., Robinson, A., & Austin, J. H. (1979). Increased aneuploidy in Alzheimer disease. American Journal of Medical Genetics, 3(2), 137-144.

Increased aneuploidy in Alzheimer disease. / Ward, B. E.; Cook-Deegan, Robert; Robinson, A.; Austin, J. H.

In: American Journal of Medical Genetics, Vol. 3, No. 2, 1979, p. 137-144.

Research output: Contribution to journalArticle

Ward, BE, Cook-Deegan, R, Robinson, A & Austin, JH 1979, 'Increased aneuploidy in Alzheimer disease', American Journal of Medical Genetics, vol. 3, no. 2, pp. 137-144.
Ward, B. E. ; Cook-Deegan, Robert ; Robinson, A. ; Austin, J. H. / Increased aneuploidy in Alzheimer disease. In: American Journal of Medical Genetics. 1979 ; Vol. 3, No. 2. pp. 137-144.
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