Increased 5-hydroxymethylation levels in the sub ventricular zone of the Alzheimer's brain

Diego Mastroeni, Leonidas Chouliaras, Daniel L. Van den Hove, Jennifer Nolz, Bart P.F. Rutten, Elaine Delvaux, Paul Coleman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The subventricular zone (SVZ) is a site of neurogenesis in the aging brain, and epigenetic mechanisms have been implicated in regulating the "normal" distribution of new nerve cells into the existing cellular milieu. In a case-control study of human primary SVZ cultures and fixed tissue from the same individuals, we have found significant increases in DNA hydroxymethylation levels in the SVZ of Alzheimer's disease patients compared with nondiseased control subjects. We show that this increase in hydroxymethylation directly correlates to an increase in cellular proliferation in Alzheimer's disease precursor cells, which implicates the hydroxymethylation tag to a higher degree of cellular proliferation.

Original languageEnglish (US)
Pages (from-to)26-31
Number of pages6
JournalNeuroepigenetics
Volume6
DOIs
StatePublished - Jun 1 2016

Fingerprint

Lateral Ventricles
Brain
Alzheimer Disease
Normal distribution
Cell Proliferation
Neurons
Aging of materials
Normal Distribution
Neurogenesis
Tissue
Epigenomics
Case-Control Studies
DNA

ASJC Scopus subject areas

  • Biochemistry
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Biological Psychiatry

Cite this

Increased 5-hydroxymethylation levels in the sub ventricular zone of the Alzheimer's brain. / Mastroeni, Diego; Chouliaras, Leonidas; Van den Hove, Daniel L.; Nolz, Jennifer; Rutten, Bart P.F.; Delvaux, Elaine; Coleman, Paul.

In: Neuroepigenetics, Vol. 6, 01.06.2016, p. 26-31.

Research output: Contribution to journalArticle

Mastroeni, Diego ; Chouliaras, Leonidas ; Van den Hove, Daniel L. ; Nolz, Jennifer ; Rutten, Bart P.F. ; Delvaux, Elaine ; Coleman, Paul. / Increased 5-hydroxymethylation levels in the sub ventricular zone of the Alzheimer's brain. In: Neuroepigenetics. 2016 ; Vol. 6. pp. 26-31.
@article{d7cab7f015f14b0e8b55eca23befd124,
title = "Increased 5-hydroxymethylation levels in the sub ventricular zone of the Alzheimer's brain",
abstract = "The subventricular zone (SVZ) is a site of neurogenesis in the aging brain, and epigenetic mechanisms have been implicated in regulating the {"}normal{"} distribution of new nerve cells into the existing cellular milieu. In a case-control study of human primary SVZ cultures and fixed tissue from the same individuals, we have found significant increases in DNA hydroxymethylation levels in the SVZ of Alzheimer's disease patients compared with nondiseased control subjects. We show that this increase in hydroxymethylation directly correlates to an increase in cellular proliferation in Alzheimer's disease precursor cells, which implicates the hydroxymethylation tag to a higher degree of cellular proliferation.",
author = "Diego Mastroeni and Leonidas Chouliaras and {Van den Hove}, {Daniel L.} and Jennifer Nolz and Rutten, {Bart P.F.} and Elaine Delvaux and Paul Coleman",
year = "2016",
month = "6",
day = "1",
doi = "10.1016/j.nepig.2016.04.002",
language = "English (US)",
volume = "6",
pages = "26--31",
journal = "Neuroepigenetics",
issn = "2214-7845",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Increased 5-hydroxymethylation levels in the sub ventricular zone of the Alzheimer's brain

AU - Mastroeni, Diego

AU - Chouliaras, Leonidas

AU - Van den Hove, Daniel L.

AU - Nolz, Jennifer

AU - Rutten, Bart P.F.

AU - Delvaux, Elaine

AU - Coleman, Paul

PY - 2016/6/1

Y1 - 2016/6/1

N2 - The subventricular zone (SVZ) is a site of neurogenesis in the aging brain, and epigenetic mechanisms have been implicated in regulating the "normal" distribution of new nerve cells into the existing cellular milieu. In a case-control study of human primary SVZ cultures and fixed tissue from the same individuals, we have found significant increases in DNA hydroxymethylation levels in the SVZ of Alzheimer's disease patients compared with nondiseased control subjects. We show that this increase in hydroxymethylation directly correlates to an increase in cellular proliferation in Alzheimer's disease precursor cells, which implicates the hydroxymethylation tag to a higher degree of cellular proliferation.

AB - The subventricular zone (SVZ) is a site of neurogenesis in the aging brain, and epigenetic mechanisms have been implicated in regulating the "normal" distribution of new nerve cells into the existing cellular milieu. In a case-control study of human primary SVZ cultures and fixed tissue from the same individuals, we have found significant increases in DNA hydroxymethylation levels in the SVZ of Alzheimer's disease patients compared with nondiseased control subjects. We show that this increase in hydroxymethylation directly correlates to an increase in cellular proliferation in Alzheimer's disease precursor cells, which implicates the hydroxymethylation tag to a higher degree of cellular proliferation.

UR - http://www.scopus.com/inward/record.url?scp=84969180332&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84969180332&partnerID=8YFLogxK

U2 - 10.1016/j.nepig.2016.04.002

DO - 10.1016/j.nepig.2016.04.002

M3 - Article

AN - SCOPUS:84969180332

VL - 6

SP - 26

EP - 31

JO - Neuroepigenetics

JF - Neuroepigenetics

SN - 2214-7845

ER -