Inbreeding depression and inferred deleterious-mutation parameters in daphnia

Hong Wen Deng, Michael Lynch

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

DENG and LYNCH recently proposed a method for estimating deleterious genomic mutation parameters from changes in the mean and genetic variance of fitness traits upon inbreeding in outcrossing populations. Such observations are readily acquired in cyclical parthenogens. Selfing and life-table experiments were performed for two such Daphnia populations. We observed a significant inbreeding depression and an increase of genetic variance for all traits analyzed. DENG and LYNCH'S original procedures were extended to estimate genomic mutation rate (U), mean dominance coefficient (h̄), mean selection coefficient (s̄), and scaled genomic mutational variance (V(m)/V(e)). On average, U, h, s and V(m)/V(e) (indicates an estimate) are 0.74, 0.30, 0.14 and 4.6E-4, respectively. For the true values, the U and h are lower bounds, and s and V(m)/V(e) upper bounds. The present U, h and V(m)/V(e) are in general concordance with earlier results. The discrepancy between the present s and that from mutation-accumulation experiments in Drosophila (~0.04) is discussed. It is shown that different reproductive modes do not affect gene frequency at mutation-selection equilibrium if mutational effects on fitness are multiplicative and not completely recessive.

Original languageEnglish (US)
Pages (from-to)147-155
Number of pages9
JournalGenetics
Volume147
Issue number1
StatePublished - Sep 1 1997
Externally publishedYes

Fingerprint

Daphnia
Genetic Fitness
Mutation
Life Tables
Inbreeding
Mutation Rate
Gene Frequency
Population
Drosophila
Inbreeding Depression
Mutation Accumulation

ASJC Scopus subject areas

  • Genetics

Cite this

Inbreeding depression and inferred deleterious-mutation parameters in daphnia. / Deng, Hong Wen; Lynch, Michael.

In: Genetics, Vol. 147, No. 1, 01.09.1997, p. 147-155.

Research output: Contribution to journalArticle

@article{26c7f5d1b5d54ea7a3fdd84d42ccb39e,
title = "Inbreeding depression and inferred deleterious-mutation parameters in daphnia",
abstract = "DENG and LYNCH recently proposed a method for estimating deleterious genomic mutation parameters from changes in the mean and genetic variance of fitness traits upon inbreeding in outcrossing populations. Such observations are readily acquired in cyclical parthenogens. Selfing and life-table experiments were performed for two such Daphnia populations. We observed a significant inbreeding depression and an increase of genetic variance for all traits analyzed. DENG and LYNCH'S original procedures were extended to estimate genomic mutation rate (U), mean dominance coefficient (h̄), mean selection coefficient (s̄), and scaled genomic mutational variance (V(m)/V(e)). On average, U, h, s and V(m)/V(e) (indicates an estimate) are 0.74, 0.30, 0.14 and 4.6E-4, respectively. For the true values, the U and h are lower bounds, and s and V(m)/V(e) upper bounds. The present U, h and V(m)/V(e) are in general concordance with earlier results. The discrepancy between the present s and that from mutation-accumulation experiments in Drosophila (~0.04) is discussed. It is shown that different reproductive modes do not affect gene frequency at mutation-selection equilibrium if mutational effects on fitness are multiplicative and not completely recessive.",
author = "Deng, {Hong Wen} and Michael Lynch",
year = "1997",
month = "9",
day = "1",
language = "English (US)",
volume = "147",
pages = "147--155",
journal = "Genetics",
issn = "0016-6731",
publisher = "Genetics Society of America",
number = "1",

}

TY - JOUR

T1 - Inbreeding depression and inferred deleterious-mutation parameters in daphnia

AU - Deng, Hong Wen

AU - Lynch, Michael

PY - 1997/9/1

Y1 - 1997/9/1

N2 - DENG and LYNCH recently proposed a method for estimating deleterious genomic mutation parameters from changes in the mean and genetic variance of fitness traits upon inbreeding in outcrossing populations. Such observations are readily acquired in cyclical parthenogens. Selfing and life-table experiments were performed for two such Daphnia populations. We observed a significant inbreeding depression and an increase of genetic variance for all traits analyzed. DENG and LYNCH'S original procedures were extended to estimate genomic mutation rate (U), mean dominance coefficient (h̄), mean selection coefficient (s̄), and scaled genomic mutational variance (V(m)/V(e)). On average, U, h, s and V(m)/V(e) (indicates an estimate) are 0.74, 0.30, 0.14 and 4.6E-4, respectively. For the true values, the U and h are lower bounds, and s and V(m)/V(e) upper bounds. The present U, h and V(m)/V(e) are in general concordance with earlier results. The discrepancy between the present s and that from mutation-accumulation experiments in Drosophila (~0.04) is discussed. It is shown that different reproductive modes do not affect gene frequency at mutation-selection equilibrium if mutational effects on fitness are multiplicative and not completely recessive.

AB - DENG and LYNCH recently proposed a method for estimating deleterious genomic mutation parameters from changes in the mean and genetic variance of fitness traits upon inbreeding in outcrossing populations. Such observations are readily acquired in cyclical parthenogens. Selfing and life-table experiments were performed for two such Daphnia populations. We observed a significant inbreeding depression and an increase of genetic variance for all traits analyzed. DENG and LYNCH'S original procedures were extended to estimate genomic mutation rate (U), mean dominance coefficient (h̄), mean selection coefficient (s̄), and scaled genomic mutational variance (V(m)/V(e)). On average, U, h, s and V(m)/V(e) (indicates an estimate) are 0.74, 0.30, 0.14 and 4.6E-4, respectively. For the true values, the U and h are lower bounds, and s and V(m)/V(e) upper bounds. The present U, h and V(m)/V(e) are in general concordance with earlier results. The discrepancy between the present s and that from mutation-accumulation experiments in Drosophila (~0.04) is discussed. It is shown that different reproductive modes do not affect gene frequency at mutation-selection equilibrium if mutational effects on fitness are multiplicative and not completely recessive.

UR - http://www.scopus.com/inward/record.url?scp=0030961064&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030961064&partnerID=8YFLogxK

M3 - Article

C2 - 9286675

AN - SCOPUS:0030961064

VL - 147

SP - 147

EP - 155

JO - Genetics

JF - Genetics

SN - 0016-6731

IS - 1

ER -