Inactivation of viruses with a very low power visible femtosecond laser

Kong-Thon Tsen; Shaw Wei D Tsen; Chih Long Chang; Chien Fu Hung; T. C. Wu; Juliann G. Kiang

doi:10.1088/0953-8984/19/32/322102

Inactivation of viruses with a very low power visible femtosecond laser

Kong-Thon Tsen, Shaw Wei D Tsen, Chih Long Chang, Chien Fu Hung, T. C. Wu, Juliann G. Kiang

Physics

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

We demonstrate for the first time that, by using a visible femtosecond laser, it is effective to inactivate viruses such as bacteriophage M13 through impulsive stimulated Raman scattering. By using a very low power visible femtosecond laser having a wavelength of 425nm and a pulse width of 100fs, we show that M13 phages were inactivated when the laser power density was greater than or equal to 50MWcm^-2. The inactivation of M13 phages was determined by plaque counts and depended on the pulse width as well as power density of the excitation laser.

Original language	English (US)
Article number	322102
Journal	Journal of Physics Condensed Matter
Volume	19
Issue number	32
DOIs	https://doi.org/10.1088/0953-8984/19/32/322102
State	Published - Aug 15 2007

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics

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abstract = "We demonstrate for the first time that, by using a visible femtosecond laser, it is effective to inactivate viruses such as bacteriophage M13 through impulsive stimulated Raman scattering. By using a very low power visible femtosecond laser having a wavelength of 425nm and a pulse width of 100fs, we show that M13 phages were inactivated when the laser power density was greater than or equal to 50MWcm-2. The inactivation of M13 phages was determined by plaque counts and depended on the pulse width as well as power density of the excitation laser.",

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AU - Tsen, Kong-Thon

AU - Tsen, Shaw Wei D

AU - Chang, Chih Long

AU - Hung, Chien Fu

AU - Wu, T. C.

AU - Kiang, Juliann G.

PY - 2007/8/15

Y1 - 2007/8/15

N2 - We demonstrate for the first time that, by using a visible femtosecond laser, it is effective to inactivate viruses such as bacteriophage M13 through impulsive stimulated Raman scattering. By using a very low power visible femtosecond laser having a wavelength of 425nm and a pulse width of 100fs, we show that M13 phages were inactivated when the laser power density was greater than or equal to 50MWcm-2. The inactivation of M13 phages was determined by plaque counts and depended on the pulse width as well as power density of the excitation laser.

AB - We demonstrate for the first time that, by using a visible femtosecond laser, it is effective to inactivate viruses such as bacteriophage M13 through impulsive stimulated Raman scattering. By using a very low power visible femtosecond laser having a wavelength of 425nm and a pulse width of 100fs, we show that M13 phages were inactivated when the laser power density was greater than or equal to 50MWcm-2. The inactivation of M13 phages was determined by plaque counts and depended on the pulse width as well as power density of the excitation laser.

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Inactivation of viruses with a very low power visible femtosecond laser

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