Inactivating Gene Expression with Antisense Modified Oligonucleotides

Sidney Altman, Carlos Angele-Martinez

Research output: Contribution to journalArticlepeer-review

Abstract

Modified nucleotides, including phosphoramidates and mesyl nucleotides, are very effective in inactivating gene expression in bacteria. Gyr A is the target gene in several organisms, including Plasmodium falciparum. Antisense reactions with bacteria infecting citrus plants are promising but incomplete. Human tissue culture cells assayed with a different target are also susceptible to the presence of mesyl oligonucleotides

Original languageEnglish (US)
Pages (from-to)101-105
Number of pages5
JournalActa Naturae
Volume13
Issue number3
DOIs
StatePublished - 2021
Externally publishedYes

Keywords

  • bacteria
  • citrus plants
  • gene expression
  • modified nucleotides
  • Plasmodium falciparum

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

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