Inactivating Gene Expression with Antisense Modified Oligonucleotides

Sidney Altman; Carlos Angele-Martinez

doi:10.32607/actanaturae.11522

Inactivating Gene Expression with Antisense Modified Oligonucleotides

Sidney Altman, Carlos Angele-Martinez

Research output: Contribution to journal › Article › peer-review

Abstract

Modified nucleotides, including phosphoramidates and mesyl nucleotides, are very effective in inactivating gene expression in bacteria. Gyr A is the target gene in several organisms, including Plasmodium falciparum. Antisense reactions with bacteria infecting citrus plants are promising but incomplete. Human tissue culture cells assayed with a different target are also susceptible to the presence of mesyl oligonucleotides

Original language	English (US)
Pages (from-to)	101-105
Number of pages	5
Journal	Acta Naturae
Volume	13
Issue number	3
DOIs	https://doi.org/10.32607/actanaturae.11522
State	Published - 2021
Externally published	Yes

Keywords

bacteria
citrus plants
gene expression
modified nucleotides
Plasmodium falciparum

ASJC Scopus subject areas

Biotechnology
Biochemistry
Molecular Medicine
Molecular Biology

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10.32607/actanaturae.11522

Cite this

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abstract = "Modified nucleotides, including phosphoramidates and mesyl nucleotides, are very effective in inactivating gene expression in bacteria. Gyr A is the target gene in several organisms, including Plasmodium falciparum. Antisense reactions with bacteria infecting citrus plants are promising but incomplete. Human tissue culture cells assayed with a different target are also susceptible to the presence of mesyl oligonucleotides",

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AB - Modified nucleotides, including phosphoramidates and mesyl nucleotides, are very effective in inactivating gene expression in bacteria. Gyr A is the target gene in several organisms, including Plasmodium falciparum. Antisense reactions with bacteria infecting citrus plants are promising but incomplete. Human tissue culture cells assayed with a different target are also susceptible to the presence of mesyl oligonucleotides

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KW - citrus plants

KW - gene expression

KW - modified nucleotides

KW - Plasmodium falciparum

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Inactivating Gene Expression with Antisense Modified Oligonucleotides

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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