Abstract
Modified nucleotides, including phosphoramidates and mesyl nucleotides, are very effective in inactivating gene expression in bacteria. Gyr A is the target gene in several organisms, including Plasmodium falciparum. Antisense reactions with bacteria infecting citrus plants are promising but incomplete. Human tissue culture cells assayed with a different target are also susceptible to the presence of mesyl oligonucleotides
Original language | English (US) |
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Pages (from-to) | 101-105 |
Number of pages | 5 |
Journal | Acta Naturae |
Volume | 13 |
Issue number | 3 |
DOIs | |
State | Published - 2021 |
Externally published | Yes |
Keywords
- bacteria
- citrus plants
- gene expression
- modified nucleotides
- Plasmodium falciparum
ASJC Scopus subject areas
- Biotechnology
- Biochemistry
- Molecular Medicine
- Molecular Biology