In vivo experimental aneurysm embolization in a swine model with a liquid-to-solid gelling polymer system: Initial biocompatibility and delivery strategy analysis

Celeste R. Brennecka, Mark C. Preul, William D. Bichard, Brent Vernon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: Current treatments for cerebral aneurysms are far from ideal. Platinum coils are prone to compaction, and currently used liquid embolics are delivered with angiotoxic agents. This work presents initial in vivo studies of a novel liquid-to-solid gelling polymer system (PPODA-QT), focusing on biocompatibility and effective delivery strategies. Methods: PPODA-QT was used to embolize surgically created lateral wall carotid artery aneurysms in swine using three delivery strategies. Group 1 aneurysms were completely filled with PPODA-QT (n = 5), group 2 aneurysms were subcompletely (80%-90%) filled (n = 3), and group 3 aneurysms underwent three-dimensional coil placement followed by polymer embolization (n = 3). The study was designed such that three animals per treatment group survived to 1 month. Results: The group 1 delivery strategy (100% filling) resulted in survival of 3/5 animals. This strategy led to aneurysm stretching, which resulted model failure in 2/5 animals. Group 2 aneurysms, although initially <100% filled with the polymer, displayed robust neointimal tissue coverage and complete obliteration after 1 month. Group 3 aneurysms showed less prominent neointimal tissue coverage as well as two instances where excess polymer was found in the parent vessel. The PPODA-QT material showed good biocompatibility with vascular tissue in all animals at 1 month. Conclusions: This small-scale pilot study highlighted first-time in vivo use of PPODA-QT as an embolic agent for aneurysm treatment. Filling aneurysms to 80% to 90% capacity proved to be a safe and effective delivery strategy, and PPODA-QT showed excellent biocompatibility. This study indicates that future investigation of PPODA-QT for aneurysm embolization is warranted, as it may prove to be a viable alternative to current embolic materials.

Original languageEnglish (US)
Pages (from-to)469-480
Number of pages12
JournalWorld Neurosurgery
Volume78
Issue number5
DOIs
StatePublished - Nov 2012

Fingerprint

Aneurysm
Polymers
Swine
Intracranial Aneurysm
Platinum
Carotid Arteries
Blood Vessels

Keywords

  • Biocompatibility testing
  • Cerebral aneurysm
  • Cross-linking polymer
  • Endovascular techniques
  • Therapeutic embolization

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

In vivo experimental aneurysm embolization in a swine model with a liquid-to-solid gelling polymer system : Initial biocompatibility and delivery strategy analysis. / Brennecka, Celeste R.; Preul, Mark C.; Bichard, William D.; Vernon, Brent.

In: World Neurosurgery, Vol. 78, No. 5, 11.2012, p. 469-480.

Research output: Contribution to journalArticle

@article{14e84a0c22da40bba71e3bf1b8bd41d1,
title = "In vivo experimental aneurysm embolization in a swine model with a liquid-to-solid gelling polymer system: Initial biocompatibility and delivery strategy analysis",
abstract = "Objective: Current treatments for cerebral aneurysms are far from ideal. Platinum coils are prone to compaction, and currently used liquid embolics are delivered with angiotoxic agents. This work presents initial in vivo studies of a novel liquid-to-solid gelling polymer system (PPODA-QT), focusing on biocompatibility and effective delivery strategies. Methods: PPODA-QT was used to embolize surgically created lateral wall carotid artery aneurysms in swine using three delivery strategies. Group 1 aneurysms were completely filled with PPODA-QT (n = 5), group 2 aneurysms were subcompletely (80{\%}-90{\%}) filled (n = 3), and group 3 aneurysms underwent three-dimensional coil placement followed by polymer embolization (n = 3). The study was designed such that three animals per treatment group survived to 1 month. Results: The group 1 delivery strategy (100{\%} filling) resulted in survival of 3/5 animals. This strategy led to aneurysm stretching, which resulted model failure in 2/5 animals. Group 2 aneurysms, although initially <100{\%} filled with the polymer, displayed robust neointimal tissue coverage and complete obliteration after 1 month. Group 3 aneurysms showed less prominent neointimal tissue coverage as well as two instances where excess polymer was found in the parent vessel. The PPODA-QT material showed good biocompatibility with vascular tissue in all animals at 1 month. Conclusions: This small-scale pilot study highlighted first-time in vivo use of PPODA-QT as an embolic agent for aneurysm treatment. Filling aneurysms to 80{\%} to 90{\%} capacity proved to be a safe and effective delivery strategy, and PPODA-QT showed excellent biocompatibility. This study indicates that future investigation of PPODA-QT for aneurysm embolization is warranted, as it may prove to be a viable alternative to current embolic materials.",
keywords = "Biocompatibility testing, Cerebral aneurysm, Cross-linking polymer, Endovascular techniques, Therapeutic embolization",
author = "Brennecka, {Celeste R.} and Preul, {Mark C.} and Bichard, {William D.} and Brent Vernon",
year = "2012",
month = "11",
doi = "10.1016/j.wneu.2011.10.029",
language = "English (US)",
volume = "78",
pages = "469--480",
journal = "World Neurosurgery",
issn = "1878-8750",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - In vivo experimental aneurysm embolization in a swine model with a liquid-to-solid gelling polymer system

T2 - Initial biocompatibility and delivery strategy analysis

AU - Brennecka, Celeste R.

AU - Preul, Mark C.

AU - Bichard, William D.

AU - Vernon, Brent

PY - 2012/11

Y1 - 2012/11

N2 - Objective: Current treatments for cerebral aneurysms are far from ideal. Platinum coils are prone to compaction, and currently used liquid embolics are delivered with angiotoxic agents. This work presents initial in vivo studies of a novel liquid-to-solid gelling polymer system (PPODA-QT), focusing on biocompatibility and effective delivery strategies. Methods: PPODA-QT was used to embolize surgically created lateral wall carotid artery aneurysms in swine using three delivery strategies. Group 1 aneurysms were completely filled with PPODA-QT (n = 5), group 2 aneurysms were subcompletely (80%-90%) filled (n = 3), and group 3 aneurysms underwent three-dimensional coil placement followed by polymer embolization (n = 3). The study was designed such that three animals per treatment group survived to 1 month. Results: The group 1 delivery strategy (100% filling) resulted in survival of 3/5 animals. This strategy led to aneurysm stretching, which resulted model failure in 2/5 animals. Group 2 aneurysms, although initially <100% filled with the polymer, displayed robust neointimal tissue coverage and complete obliteration after 1 month. Group 3 aneurysms showed less prominent neointimal tissue coverage as well as two instances where excess polymer was found in the parent vessel. The PPODA-QT material showed good biocompatibility with vascular tissue in all animals at 1 month. Conclusions: This small-scale pilot study highlighted first-time in vivo use of PPODA-QT as an embolic agent for aneurysm treatment. Filling aneurysms to 80% to 90% capacity proved to be a safe and effective delivery strategy, and PPODA-QT showed excellent biocompatibility. This study indicates that future investigation of PPODA-QT for aneurysm embolization is warranted, as it may prove to be a viable alternative to current embolic materials.

AB - Objective: Current treatments for cerebral aneurysms are far from ideal. Platinum coils are prone to compaction, and currently used liquid embolics are delivered with angiotoxic agents. This work presents initial in vivo studies of a novel liquid-to-solid gelling polymer system (PPODA-QT), focusing on biocompatibility and effective delivery strategies. Methods: PPODA-QT was used to embolize surgically created lateral wall carotid artery aneurysms in swine using three delivery strategies. Group 1 aneurysms were completely filled with PPODA-QT (n = 5), group 2 aneurysms were subcompletely (80%-90%) filled (n = 3), and group 3 aneurysms underwent three-dimensional coil placement followed by polymer embolization (n = 3). The study was designed such that three animals per treatment group survived to 1 month. Results: The group 1 delivery strategy (100% filling) resulted in survival of 3/5 animals. This strategy led to aneurysm stretching, which resulted model failure in 2/5 animals. Group 2 aneurysms, although initially <100% filled with the polymer, displayed robust neointimal tissue coverage and complete obliteration after 1 month. Group 3 aneurysms showed less prominent neointimal tissue coverage as well as two instances where excess polymer was found in the parent vessel. The PPODA-QT material showed good biocompatibility with vascular tissue in all animals at 1 month. Conclusions: This small-scale pilot study highlighted first-time in vivo use of PPODA-QT as an embolic agent for aneurysm treatment. Filling aneurysms to 80% to 90% capacity proved to be a safe and effective delivery strategy, and PPODA-QT showed excellent biocompatibility. This study indicates that future investigation of PPODA-QT for aneurysm embolization is warranted, as it may prove to be a viable alternative to current embolic materials.

KW - Biocompatibility testing

KW - Cerebral aneurysm

KW - Cross-linking polymer

KW - Endovascular techniques

KW - Therapeutic embolization

UR - http://www.scopus.com/inward/record.url?scp=84868563812&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868563812&partnerID=8YFLogxK

U2 - 10.1016/j.wneu.2011.10.029

DO - 10.1016/j.wneu.2011.10.029

M3 - Article

C2 - 22120570

AN - SCOPUS:84868563812

VL - 78

SP - 469

EP - 480

JO - World Neurosurgery

JF - World Neurosurgery

SN - 1878-8750

IS - 5

ER -