In vivo distribution and dynamics of DNA topoisomerase II in drosophila embryonic nuclei and chromosomes

Jason R. Swedlow; Neil Osheroff; Tim Karr; John W. Sedat; David A. Agard

In vivo distribution and dynamics of DNA topoisomerase II in drosophila embryonic nuclei and chromosomes

Jason R. Swedlow, Neil Osheroff, Tim Karr, John W. Sedat, David A. Agard

Research output: Contribution to journal › Conference article › peer-review

Abstract

DNA topoisomerase II is an ATP-dependent double-stranded DNA strand-passing enzyme that is necessary for full condensation of chromosomes and for complete segregation of sister chromatids at mitosis in vivo and in vitro. The chromosomal distribution of topoisomerase II in vivo is monitored during mitosis in the Drosophila embryo. For this experiment, the embryonic nuclei synchronously progress through 13 mitotic cycles, an ideal system to follow nuclear and chromosomal dynamics.

Original language	English (US)
Pages (from-to)	74-75
Number of pages	2
Journal	Proceedings - Annual Meeting, Microscopy Society of America
State	Published - Dec 1 1993
Externally published	Yes
Event	Proceedings of the 51st Annual Meeting Microscopy Society of America - Cincinnati, OH, USA Duration: Aug 1 1993 → Aug 6 1993

ASJC Scopus subject areas

Engineering(all)

Cite this

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title = "In vivo distribution and dynamics of DNA topoisomerase II in drosophila embryonic nuclei and chromosomes",

abstract = "DNA topoisomerase II is an ATP-dependent double-stranded DNA strand-passing enzyme that is necessary for full condensation of chromosomes and for complete segregation of sister chromatids at mitosis in vivo and in vitro. The chromosomal distribution of topoisomerase II in vivo is monitored during mitosis in the Drosophila embryo. For this experiment, the embryonic nuclei synchronously progress through 13 mitotic cycles, an ideal system to follow nuclear and chromosomal dynamics.",

author = "Swedlow, {Jason R.} and Neil Osheroff and Tim Karr and Sedat, {John W.} and Agard, {David A.}",

year = "1993",

month = dec,

day = "1",

language = "English (US)",

pages = "74--75",

journal = "Proceedings - Annual Meeting, Microscopy Society of America",

issn = "0424-8201",

note = "Proceedings of the 51st Annual Meeting Microscopy Society of America ; Conference date: 01-08-1993 Through 06-08-1993",

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TY - JOUR

T1 - In vivo distribution and dynamics of DNA topoisomerase II in drosophila embryonic nuclei and chromosomes

AU - Swedlow, Jason R.

AU - Osheroff, Neil

AU - Karr, Tim

AU - Sedat, John W.

AU - Agard, David A.

PY - 1993/12/1

Y1 - 1993/12/1

N2 - DNA topoisomerase II is an ATP-dependent double-stranded DNA strand-passing enzyme that is necessary for full condensation of chromosomes and for complete segregation of sister chromatids at mitosis in vivo and in vitro. The chromosomal distribution of topoisomerase II in vivo is monitored during mitosis in the Drosophila embryo. For this experiment, the embryonic nuclei synchronously progress through 13 mitotic cycles, an ideal system to follow nuclear and chromosomal dynamics.

AB - DNA topoisomerase II is an ATP-dependent double-stranded DNA strand-passing enzyme that is necessary for full condensation of chromosomes and for complete segregation of sister chromatids at mitosis in vivo and in vitro. The chromosomal distribution of topoisomerase II in vivo is monitored during mitosis in the Drosophila embryo. For this experiment, the embryonic nuclei synchronously progress through 13 mitotic cycles, an ideal system to follow nuclear and chromosomal dynamics.

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UR - http://www.scopus.com/inward/citedby.url?scp=0027706002&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0027706002

SN - 0424-8201

SP - 74

EP - 75

JO - Proceedings - Annual Meeting, Microscopy Society of America

JF - Proceedings - Annual Meeting, Microscopy Society of America

T2 - Proceedings of the 51st Annual Meeting Microscopy Society of America

Y2 - 1 August 1993 through 6 August 1993

ER -

In vivo distribution and dynamics of DNA topoisomerase II in drosophila embryonic nuclei and chromosomes

Abstract

ASJC Scopus subject areas

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