In vitro characterization of a nineteenth-century therapy for smallpox

William Arndt, Chandra Mitnik, Karen L. Denzler, Stacy White, Robert Waters, Bertram Jacobs, Yvan Rochon, Victoria A. Olson, Inger K. Damon, Jeffrey Langland

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In the nineteenth century, smallpox ravaged through the United States and Canada. At this time, a botanical preparation, derived from the carnivorous plant Sarracenia purpurea, was proclaimed as being a successful therapy for smallpox infections. The work described characterizes the antipoxvirus activity associated with this botanical extract against vaccinia virus, monkeypox virus and variola virus, the causative agent of smallpox. Our work demonstrates the in vitro characterization of Sarracenia purpurea as the first effective inhibitor of poxvirus replication at the level of early viral transcription. With the renewed threat of poxvirus-related infections, our results indicate Sarracenia purpurea may act as another defensive measure against Orthopoxvirus infections.

Original languageEnglish (US)
Article numbere32610
JournalPLoS One
Volume7
Issue number3
DOIs
StatePublished - Mar 9 2012

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Sarraceniaceae
Smallpox
Poxviridae
Viruses
therapeutics
Monkeypox virus
Poxviridae Infections
Variola virus
Orthopoxvirus
infection
carnivorous plants
Vaccinia virus
Transcription
Infection
Canada
Therapeutics
extracts
In Vitro Techniques
Sarracenia purpurea

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

In vitro characterization of a nineteenth-century therapy for smallpox. / Arndt, William; Mitnik, Chandra; Denzler, Karen L.; White, Stacy; Waters, Robert; Jacobs, Bertram; Rochon, Yvan; Olson, Victoria A.; Damon, Inger K.; Langland, Jeffrey.

In: PLoS One, Vol. 7, No. 3, e32610, 09.03.2012.

Research output: Contribution to journalArticle

Arndt, W, Mitnik, C, Denzler, KL, White, S, Waters, R, Jacobs, B, Rochon, Y, Olson, VA, Damon, IK & Langland, J 2012, 'In vitro characterization of a nineteenth-century therapy for smallpox', PLoS One, vol. 7, no. 3, e32610. https://doi.org/10.1371/journal.pone.0032610
Arndt, William ; Mitnik, Chandra ; Denzler, Karen L. ; White, Stacy ; Waters, Robert ; Jacobs, Bertram ; Rochon, Yvan ; Olson, Victoria A. ; Damon, Inger K. ; Langland, Jeffrey. / In vitro characterization of a nineteenth-century therapy for smallpox. In: PLoS One. 2012 ; Vol. 7, No. 3.
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