In-situ injectable physically and chemically gelling NIPAAm-based copolymer system for embolization

Bae Hoon Lee, Bianca West, Ryan McLemore, Christine Pauken, Brent Vernon

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The goal of this work is to make an injectable physically and chemically cross-linking NIPAAm-based copolymer system for endovascular embolization. A copolymer with N-isopropylacrylamide (NIPAAm) and hydroxyethyl methacrylate (HEMA) was synthesized and converted to poly(NIPAAm-co-HEMA-acrylate) functionalized with olefins. When poly(NIPAAm-co-HEMA-acrylate) was mixed with pentaerythritol tetrakis 3-mercaptopropionate (QT) stoichiometrically in a 0.1 N PBS solution of pH 7.4, it formed a temperature-sensitive hydrogel with low swelling through the Michael-type addition reaction and showed improved elastic properties at low frequency compared to physical gelation. This material could be useful for applications requiring water-soluble injection but lower swelling and lower creep properties than available with other soluble in-situ-gelling materials.

Original languageEnglish (US)
Pages (from-to)2059-2064
Number of pages6
JournalBiomacromolecules
Volume7
Issue number6
DOIs
StatePublished - Jun 2006

Fingerprint

Swelling
Copolymers
Addition reactions
Injections
Water injection
Hydrogel
Alkenes
Gelation
Hydrogels
Olefins
Creep
Temperature
Water
poly(N-isopropylacrylamide-co-hydroxyethyl methacrylate-acrylate)
N-isopropylacrylamide
hydroxyethyl methacrylate
pentaerythritol

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Polymers and Plastics
  • Materials Chemistry

Cite this

In-situ injectable physically and chemically gelling NIPAAm-based copolymer system for embolization. / Lee, Bae Hoon; West, Bianca; McLemore, Ryan; Pauken, Christine; Vernon, Brent.

In: Biomacromolecules, Vol. 7, No. 6, 06.2006, p. 2059-2064.

Research output: Contribution to journalArticle

Lee, Bae Hoon ; West, Bianca ; McLemore, Ryan ; Pauken, Christine ; Vernon, Brent. / In-situ injectable physically and chemically gelling NIPAAm-based copolymer system for embolization. In: Biomacromolecules. 2006 ; Vol. 7, No. 6. pp. 2059-2064.
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