In-situ injectable physically and chemically gelling NIPAAm-based copolymer system for embolization

Bae Hoon Lee; Bianca West; Ryan McLemore; Christine Pauken; Brent Vernon

doi:10.1021/bm060211h

In-situ injectable physically and chemically gelling NIPAAm-based copolymer system for embolization

Bae Hoon Lee, Bianca West, Ryan McLemore, Christine Pauken, Brent Vernon

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

The goal of this work is to make an injectable physically and chemically cross-linking NIPAAm-based copolymer system for endovascular embolization. A copolymer with N-isopropylacrylamide (NIPAAm) and hydroxyethyl methacrylate (HEMA) was synthesized and converted to poly(NIPAAm-co-HEMA-acrylate) functionalized with olefins. When poly(NIPAAm-co-HEMA-acrylate) was mixed with pentaerythritol tetrakis 3-mercaptopropionate (QT) stoichiometrically in a 0.1 N PBS solution of pH 7.4, it formed a temperature-sensitive hydrogel with low swelling through the Michael-type addition reaction and showed improved elastic properties at low frequency compared to physical gelation. This material could be useful for applications requiring water-soluble injection but lower swelling and lower creep properties than available with other soluble in-situ-gelling materials.

Original language	English (US)
Pages (from-to)	2059-2064
Number of pages	6
Journal	Biomacromolecules
Volume	7
Issue number	6
DOIs	https://doi.org/10.1021/bm060211h
State	Published - Jun 2006

ASJC Scopus subject areas

Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

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10.1021/bm060211h

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title = "In-situ injectable physically and chemically gelling NIPAAm-based copolymer system for embolization",

abstract = "The goal of this work is to make an injectable physically and chemically cross-linking NIPAAm-based copolymer system for endovascular embolization. A copolymer with N-isopropylacrylamide (NIPAAm) and hydroxyethyl methacrylate (HEMA) was synthesized and converted to poly(NIPAAm-co-HEMA-acrylate) functionalized with olefins. When poly(NIPAAm-co-HEMA-acrylate) was mixed with pentaerythritol tetrakis 3-mercaptopropionate (QT) stoichiometrically in a 0.1 N PBS solution of pH 7.4, it formed a temperature-sensitive hydrogel with low swelling through the Michael-type addition reaction and showed improved elastic properties at low frequency compared to physical gelation. This material could be useful for applications requiring water-soluble injection but lower swelling and lower creep properties than available with other soluble in-situ-gelling materials.",

author = "Lee, {Bae Hoon} and Bianca West and Ryan McLemore and Christine Pauken and Brent Vernon",

year = "2006",

month = jun,

doi = "10.1021/bm060211h",

language = "English (US)",

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T1 - In-situ injectable physically and chemically gelling NIPAAm-based copolymer system for embolization

AU - Lee, Bae Hoon

AU - West, Bianca

AU - McLemore, Ryan

AU - Pauken, Christine

AU - Vernon, Brent

PY - 2006/6

Y1 - 2006/6

N2 - The goal of this work is to make an injectable physically and chemically cross-linking NIPAAm-based copolymer system for endovascular embolization. A copolymer with N-isopropylacrylamide (NIPAAm) and hydroxyethyl methacrylate (HEMA) was synthesized and converted to poly(NIPAAm-co-HEMA-acrylate) functionalized with olefins. When poly(NIPAAm-co-HEMA-acrylate) was mixed with pentaerythritol tetrakis 3-mercaptopropionate (QT) stoichiometrically in a 0.1 N PBS solution of pH 7.4, it formed a temperature-sensitive hydrogel with low swelling through the Michael-type addition reaction and showed improved elastic properties at low frequency compared to physical gelation. This material could be useful for applications requiring water-soluble injection but lower swelling and lower creep properties than available with other soluble in-situ-gelling materials.

AB - The goal of this work is to make an injectable physically and chemically cross-linking NIPAAm-based copolymer system for endovascular embolization. A copolymer with N-isopropylacrylamide (NIPAAm) and hydroxyethyl methacrylate (HEMA) was synthesized and converted to poly(NIPAAm-co-HEMA-acrylate) functionalized with olefins. When poly(NIPAAm-co-HEMA-acrylate) was mixed with pentaerythritol tetrakis 3-mercaptopropionate (QT) stoichiometrically in a 0.1 N PBS solution of pH 7.4, it formed a temperature-sensitive hydrogel with low swelling through the Michael-type addition reaction and showed improved elastic properties at low frequency compared to physical gelation. This material could be useful for applications requiring water-soluble injection but lower swelling and lower creep properties than available with other soluble in-situ-gelling materials.

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ER -

In-situ injectable physically and chemically gelling NIPAAm-based copolymer system for embolization

Abstract

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