In-situ injectable physically and chemically gelling NIPAAm-based copolymer system for embolization

Bae Hoon Lee, Bianca West, Ryan McLemore, Christine Pauken, Brent Vernon

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

The goal of this work is to make an injectable physically and chemically cross-linking NIPAAm-based copolymer system for endovascular embolization. A copolymer with N-isopropylacrylamide (NIPAAm) and hydroxyethyl methacrylate (HEMA) was synthesized and converted to poly(NIPAAm-co-HEMA-acrylate) functionalized with olefins. When poly(NIPAAm-co-HEMA-acrylate) was mixed with pentaerythritol tetrakis 3-mercaptopropionate (QT) stoichiometrically in a 0.1 N PBS solution of pH 7.4, it formed a temperature-sensitive hydrogel with low swelling through the Michael-type addition reaction and showed improved elastic properties at low frequency compared to physical gelation. This material could be useful for applications requiring water-soluble injection but lower swelling and lower creep properties than available with other soluble in-situ-gelling materials.

Original languageEnglish (US)
Pages (from-to)2059-2064
Number of pages6
JournalBiomacromolecules
Volume7
Issue number6
DOIs
StatePublished - Jun 2006

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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