In situ-gelling, erodible N-isopropylacrylamide copolymers

Bae Hoon Lee, Brent Vernon

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Copolymers of N-isopropylacrylamide, 2-hydroxyethyl methaoryl lactate [(HEMA)-lactate] and acrylic acid (AAc) were prepared with varying mole ratios of monomers to develop copolymers with gelation properties above a certain concentration for a bioerodible, in-situ gelling material. The copolymers formed gels in situ under physiological condition. The gelation temperature of the copolymers decreased as the HEMA-lactate content of the copolymers increased due to the hydrophobicity of HEMA-lactate, and increased as the AAc content increased due to the hydrophilicity of AAc. The gels redissolve at 37°C as their LCSTs increase above 37°C due to the hydrolysis of the HEMA-lactate pendant groups.

Original languageEnglish (US)
Pages (from-to)629-635
Number of pages7
JournalMacromolecular Bioscience
Volume5
Issue number7
DOIs
StatePublished - Jul 14 2005

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Keywords

  • Bioerodible
  • Gelation
  • Injectable
  • PNIPAAm
  • Stimuli-sensitive polymers

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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