In ovo vaccination of specific-pathogen-free chickens with vaccines containing multiple agents

Maja Gagic, Catherine A. St. Hill, J. M. Sharma

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

We used in ovo technology to protect chickens against multiple diseases by inoculating vaccines containing mixtures of live viral agents. A single in ovo injection of a vaccine containing serotypes 1, 2, and 3 of Marek's disease virus (MDV), a vaccine strain of serotype 1 infectious bursal disease virus (IBDV), and recombinant fowl pox vaccine with HN and F genes of Newcastle disease virus (rFP-NDV) induced protection against virulent MDV, IBDV, Newcastle disease virus, and fowl poxvirus. The multiple-agent vaccine induced specific antibodies against the viral agents present in the mixture and did not adversely affect the survival of hatched chickens. Inoculation of a vaccine containing serotypes 1, 2, and 3 of MDV and IBDV did not affect hatchability of eggs, although the addition of rFP-NDV to the mixture reduced hatchability by 23%-26%. In ovo vaccination with a vaccine containing MDV and IBDV vaccine viruses did not exacerbate the inhibitory effect of individual viral agents on humoral and cellular immune competence.

Original languageEnglish (US)
Pages (from-to)293-301
Number of pages9
JournalAvian diseases
Volume43
Issue number2
DOIs
StatePublished - Jan 1 1999

Keywords

  • Fowl pox
  • Immunosuppression
  • In ovo vaccination
  • Infectious bursal disease
  • Marek's disease
  • Multiple-agent vaccine
  • Newcastle disease

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology
  • Immunology and Microbiology(all)

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