Improving the efficiency of antisense and EGS methods

Reza Salavati, Sidney Altman

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Hammerhead ribozymes and stable stem loop structures function as inhibitors of 3'-5'-exonuclease degradation of external guide sequences (EGSs) when covalently linked to the 3'-end of EGS RNAs. This observation may be of use in improving the efficiency of gene inactivation techniques that use single-stranded RNA (e.g., antisense RNA, EGS RNA) in vivo.

Original languageEnglish (US)
Pages (from-to)63-65
Number of pages3
JournalAntisense and Nucleic Acid Drug Development
Volume8
Issue number1
DOIs
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Pharmacology

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