Abstract
Hammerhead ribozymes and stable stem loop structures function as inhibitors of 3'-5'-exonuclease degradation of external guide sequences (EGSs) when covalently linked to the 3'-end of EGS RNAs. This observation may be of use in improving the efficiency of gene inactivation techniques that use single-stranded RNA (e.g., antisense RNA, EGS RNA) in vivo.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 63-65 |
| Number of pages | 3 |
| Journal | Antisense and Nucleic Acid Drug Development |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1998 |
| Externally published | Yes |
ASJC Scopus subject areas
- Genetics
- Pharmacology