Improving the efficiency of antisense and EGS methods

Reza Salavati, Sidney Altman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hammerhead ribozymes and stable stem loop structures function as inhibitors of 3'-5'-exonuclease degradation of external guide sequences (EGSs) when covalently linked to the 3'-end of EGS RNAs. This observation may be of use in improving the efficiency of gene inactivation techniques that use single-stranded RNA (e.g., antisense RNA, EGS RNA) in vivo.

Original languageEnglish (US)
Pages (from-to)63-65
Number of pages3
JournalAntisense and Nucleic Acid Drug Development
Volume8
Issue number1
StatePublished - 1998
Externally publishedYes

Fingerprint

Guide RNA
Antisense RNA
Exonucleases
Gene Silencing
RNA
Corrosion inhibitors
Genes
Degradation
hammerhead ribozyme

ASJC Scopus subject areas

  • Genetics
  • Pharmacology

Cite this

Improving the efficiency of antisense and EGS methods. / Salavati, Reza; Altman, Sidney.

In: Antisense and Nucleic Acid Drug Development, Vol. 8, No. 1, 1998, p. 63-65.

Research output: Contribution to journalArticle

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