Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression

Paul Davies, Lloyd A. Demetrius, Jack A. Tuszynski

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Empirical studies give increased support for the hypothesis that the sporadic form of cancer is an age-related metabolic disease characterized by: (a) metabolic dysregulation with random abnormalities in mitochondrial DNA, and (b) metabolic alteration - the compensatory upregulation of glycolysis to offset mitochondrial impairments. This paper appeals to the theory of Quantum Metabolism and the principles of natural selection to formulate a conceptual framework for a quantitative analysis of the origin and proliferation of the disease. Quantum Metabolism, an analytical theory of energy transduction in cells inspired by the methodology of the quantum theory of solids, elucidates the molecular basis for differences in metabolic rate between normal cells, utilizing predominantly oxidative phosphorylation, and cancer cells utilizing predominantly glycolysis. The principles of natural selection account for the outcome of competition between the two classes of cells. Quantum Metabolism and the principles of natural selection give an ontogenic and evolutionary rationale for cancer proliferation and furnish a framework for effective therapeutic strategies to impede the spread of the disease.

Original languageEnglish (US)
Article number011101
JournalAIP Advances
Volume2
Issue number1
DOIs
StatePublished - 2012

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metabolism
glycolysis
progressions
tumors
cancer
metabolic diseases
cells
phosphorylation
impairment
abnormalities
quantum theory
quantitative analysis
deoxyribonucleic acid
methodology
energy

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression. / Davies, Paul; Demetrius, Lloyd A.; Tuszynski, Jack A.

In: AIP Advances, Vol. 2, No. 1, 011101, 2012.

Research output: Contribution to journalArticle

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