Implications of new understandings of gliomas in children and adults with NF1: Report of a consensus conference

Roger J. Packer, Antonio Iavarone, David T.W. Jones, Jaishri O. Blakeley, Eric Bouffet, Michael J. Fisher, Eugene Hwang, Cynthia Hawkins, Lindsay Kilburn, Tobey MacDonald, Stefan M. Pfister, Brian Rood, Fausto J. Rodriguez, Uri Tabori, Vijay Ramaswamy, Yuan Zhu, Jason Fangusaro, Stephen A. Johnston, David H. Gutmann

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Gliomas are the most common primary central nervous system tumors occurring in children and adults with neurofibromatosis type 1 (NF1). Over the past decade, discoveries of the molecular basis of low-grade gliomas (LGGs) have led to new approaches for diagnosis and treatments. However, these new understandings have not been fully applied to the management of NF1-associated gliomas. A consensus panel consisting of experts in NF1 and gliomas was convened to review the current molecular knowledge of NF1-associated low-grade "transformed" and high-grade gliomas; insights gained from mouse models of NF1-LGGs; challenges in diagnosing and treating older patients with NF1-associated gliomas; and advances in molecularly targeted treatment and potential immunologic treatment of these tumors. Next steps are recommended to advance the management and outcomes for NF1-associated gliomas.

Original languageEnglish (US)
Pages (from-to)773-784
Number of pages12
JournalNeuro-Oncology
Volume22
Issue number6
DOIs
StatePublished - Jun 9 2020

Keywords

  • gliomas
  • immunotherapy
  • molecular-targeted therapy
  • neurofibromatosis type 1
  • pilocytic astrocytomas

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

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    Packer, R. J., Iavarone, A., Jones, D. T. W., Blakeley, J. O., Bouffet, E., Fisher, M. J., Hwang, E., Hawkins, C., Kilburn, L., MacDonald, T., Pfister, S. M., Rood, B., Rodriguez, F. J., Tabori, U., Ramaswamy, V., Zhu, Y., Fangusaro, J., Johnston, S. A., & Gutmann, D. H. (2020). Implications of new understandings of gliomas in children and adults with NF1: Report of a consensus conference. Neuro-Oncology, 22(6), 773-784. https://doi.org/10.1093/neuonc/noaa036