Immunosuppressive Strategies to Improve Outcomes of Kidney Transplantation

Ignatius Y. Tang, Herwig Ulf Meier-Kriesche, Bruce Kaplan

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Summary: The introduction of several immunosuppressive agents over the past decade has reduced the rate of acute rejection significantly and has improved short-term renal allograft survival. However, their impact on long-term outcomes remains unclear. Current immunosuppressive strategies are focused on improving long-term graft and patient survival along with maintaining allograft function. The approval of the new immunosuppressive agents: rabbit antithymocyte globulin, basiliximab, daclizumab, tacrolimus, mycophenolate, and sirolimus, also has facilitated the development of steroid- and calcineurin inhibitor-sparing regimens in kidney transplantation. We discuss the impact of various immunosuppressive regimens on the outcome measures of kidney transplantation: acute rejection episodes, allograft survival, and renal function.

Original languageEnglish (US)
Pages (from-to)377-392
Number of pages16
JournalSeminars in Nephrology
Volume27
Issue number4
DOIs
StatePublished - Jul 2007
Externally publishedYes

Fingerprint

Immunosuppressive Agents
Kidney Transplantation
Allografts
Kidney
Antilymphocyte Serum
Graft Rejection
Tacrolimus
Graft Survival
Sirolimus
Steroids
Outcome Assessment (Health Care)
Rabbits

Keywords

  • allograft survival
  • Antibody induction
  • cyclosporine
  • mycophenolate
  • renal function
  • sirolimus
  • steroid withdrawal
  • tacrolimus

ASJC Scopus subject areas

  • Nephrology

Cite this

Immunosuppressive Strategies to Improve Outcomes of Kidney Transplantation. / Tang, Ignatius Y.; Meier-Kriesche, Herwig Ulf; Kaplan, Bruce.

In: Seminars in Nephrology, Vol. 27, No. 4, 07.2007, p. 377-392.

Research output: Contribution to journalArticle

Tang, Ignatius Y. ; Meier-Kriesche, Herwig Ulf ; Kaplan, Bruce. / Immunosuppressive Strategies to Improve Outcomes of Kidney Transplantation. In: Seminars in Nephrology. 2007 ; Vol. 27, No. 4. pp. 377-392.
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