Abstract
Summary: The introduction of several immunosuppressive agents over the past decade has reduced the rate of acute rejection significantly and has improved short-term renal allograft survival. However, their impact on long-term outcomes remains unclear. Current immunosuppressive strategies are focused on improving long-term graft and patient survival along with maintaining allograft function. The approval of the new immunosuppressive agents: rabbit antithymocyte globulin, basiliximab, daclizumab, tacrolimus, mycophenolate, and sirolimus, also has facilitated the development of steroid- and calcineurin inhibitor-sparing regimens in kidney transplantation. We discuss the impact of various immunosuppressive regimens on the outcome measures of kidney transplantation: acute rejection episodes, allograft survival, and renal function.
Original language | English (US) |
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Pages (from-to) | 377-392 |
Number of pages | 16 |
Journal | Seminars in Nephrology |
Volume | 27 |
Issue number | 4 |
DOIs | |
State | Published - Jul 2007 |
Keywords
- Antibody induction
- allograft survival
- cyclosporine
- mycophenolate
- renal function
- sirolimus
- steroid withdrawal
- tacrolimus
ASJC Scopus subject areas
- Nephrology