Abstract
Summary: The introduction of several immunosuppressive agents over the past decade has reduced the rate of acute rejection significantly and has improved short-term renal allograft survival. However, their impact on long-term outcomes remains unclear. Current immunosuppressive strategies are focused on improving long-term graft and patient survival along with maintaining allograft function. The approval of the new immunosuppressive agents: rabbit antithymocyte globulin, basiliximab, daclizumab, tacrolimus, mycophenolate, and sirolimus, also has facilitated the development of steroid- and calcineurin inhibitor-sparing regimens in kidney transplantation. We discuss the impact of various immunosuppressive regimens on the outcome measures of kidney transplantation: acute rejection episodes, allograft survival, and renal function.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 377-392 |
| Number of pages | 16 |
| Journal | Seminars in Nephrology |
| Volume | 27 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 2007 |
| Externally published | Yes |
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Keywords
- allograft survival
- Antibody induction
- cyclosporine
- mycophenolate
- renal function
- sirolimus
- steroid withdrawal
- tacrolimus
ASJC Scopus subject areas
- Nephrology
Cite this
Immunosuppressive Strategies to Improve Outcomes of Kidney Transplantation. / Tang, Ignatius Y.; Meier-Kriesche, Herwig Ulf; Kaplan, Bruce.
In: Seminars in Nephrology, Vol. 27, No. 4, 07.2007, p. 377-392.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunosuppressive Strategies to Improve Outcomes of Kidney Transplantation
AU - Tang, Ignatius Y.
AU - Meier-Kriesche, Herwig Ulf
AU - Kaplan, Bruce
PY - 2007/7
Y1 - 2007/7
N2 - Summary: The introduction of several immunosuppressive agents over the past decade has reduced the rate of acute rejection significantly and has improved short-term renal allograft survival. However, their impact on long-term outcomes remains unclear. Current immunosuppressive strategies are focused on improving long-term graft and patient survival along with maintaining allograft function. The approval of the new immunosuppressive agents: rabbit antithymocyte globulin, basiliximab, daclizumab, tacrolimus, mycophenolate, and sirolimus, also has facilitated the development of steroid- and calcineurin inhibitor-sparing regimens in kidney transplantation. We discuss the impact of various immunosuppressive regimens on the outcome measures of kidney transplantation: acute rejection episodes, allograft survival, and renal function.
AB - Summary: The introduction of several immunosuppressive agents over the past decade has reduced the rate of acute rejection significantly and has improved short-term renal allograft survival. However, their impact on long-term outcomes remains unclear. Current immunosuppressive strategies are focused on improving long-term graft and patient survival along with maintaining allograft function. The approval of the new immunosuppressive agents: rabbit antithymocyte globulin, basiliximab, daclizumab, tacrolimus, mycophenolate, and sirolimus, also has facilitated the development of steroid- and calcineurin inhibitor-sparing regimens in kidney transplantation. We discuss the impact of various immunosuppressive regimens on the outcome measures of kidney transplantation: acute rejection episodes, allograft survival, and renal function.
KW - allograft survival
KW - Antibody induction
KW - cyclosporine
KW - mycophenolate
KW - renal function
KW - sirolimus
KW - steroid withdrawal
KW - tacrolimus
UR - http://www.scopus.com/inward/record.url?scp=34347268366&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34347268366&partnerID=8YFLogxK
U2 - 10.1016/j.semnephrol.2007.03.002
DO - 10.1016/j.semnephrol.2007.03.002
M3 - Article
C2 - 17616271
AN - SCOPUS:34347268366
VL - 27
SP - 377
EP - 392
JO - Seminars in Nephrology
JF - Seminars in Nephrology
SN - 0270-9295
IS - 4
ER -