Immunosuppressive Strategies to Improve Outcomes of Kidney Transplantation

Ignatius Y. Tang; Herwig Ulf Meier-Kriesche; Bruce Kaplan

doi:10.1016/j.semnephrol.2007.03.002

Immunosuppressive Strategies to Improve Outcomes of Kidney Transplantation

Ignatius Y. Tang, Herwig Ulf Meier-Kriesche, Bruce Kaplan

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Summary: The introduction of several immunosuppressive agents over the past decade has reduced the rate of acute rejection significantly and has improved short-term renal allograft survival. However, their impact on long-term outcomes remains unclear. Current immunosuppressive strategies are focused on improving long-term graft and patient survival along with maintaining allograft function. The approval of the new immunosuppressive agents: rabbit antithymocyte globulin, basiliximab, daclizumab, tacrolimus, mycophenolate, and sirolimus, also has facilitated the development of steroid- and calcineurin inhibitor-sparing regimens in kidney transplantation. We discuss the impact of various immunosuppressive regimens on the outcome measures of kidney transplantation: acute rejection episodes, allograft survival, and renal function.

Original language	English (US)
Pages (from-to)	377-392
Number of pages	16
Journal	Seminars in Nephrology
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/j.semnephrol.2007.03.002
State	Published - Jul 1 2007

Keywords

Antibody induction
allograft survival
cyclosporine
mycophenolate
renal function
sirolimus
steroid withdrawal
tacrolimus

ASJC Scopus subject areas

Nephrology

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AU - Kaplan, Bruce

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KW - cyclosporine

KW - mycophenolate

KW - renal function

KW - sirolimus

KW - steroid withdrawal

KW - tacrolimus

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Immunosuppressive Strategies to Improve Outcomes of Kidney Transplantation

Abstract

Keywords

ASJC Scopus subject areas

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