Immunosuppressive Strategies to Improve Outcomes of Kidney Transplantation

Ignatius Y. Tang, Herwig Ulf Meier-Kriesche, Bruce Kaplan

    Research output: Contribution to journalArticle

    18 Scopus citations

    Abstract

    Summary: The introduction of several immunosuppressive agents over the past decade has reduced the rate of acute rejection significantly and has improved short-term renal allograft survival. However, their impact on long-term outcomes remains unclear. Current immunosuppressive strategies are focused on improving long-term graft and patient survival along with maintaining allograft function. The approval of the new immunosuppressive agents: rabbit antithymocyte globulin, basiliximab, daclizumab, tacrolimus, mycophenolate, and sirolimus, also has facilitated the development of steroid- and calcineurin inhibitor-sparing regimens in kidney transplantation. We discuss the impact of various immunosuppressive regimens on the outcome measures of kidney transplantation: acute rejection episodes, allograft survival, and renal function.

    Original languageEnglish (US)
    Pages (from-to)377-392
    Number of pages16
    JournalSeminars in Nephrology
    Volume27
    Issue number4
    DOIs
    StatePublished - Jul 1 2007

    Keywords

    • Antibody induction
    • allograft survival
    • cyclosporine
    • mycophenolate
    • renal function
    • sirolimus
    • steroid withdrawal
    • tacrolimus

    ASJC Scopus subject areas

    • Nephrology

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