Immunosuppression associated with chronic inflammation in the tumor microenvironment

Dingzhi Wang, Raymond N. Du Bois

Research output: Contribution to journalArticle

109 Scopus citations

Abstract

Chronic inflammation contributes to cancer development via multiple mechanisms. One potential mechanism is that chronic inflammation can generate an immunosuppressive microenvironment that allows advantages for tumor formation and progression. The immunosuppressive environment in certain chronic inflammatory diseases and solid cancers is characterized by accumulation of proinflammatory mediators, infiltration of immune suppressor cells and activation of immune checkpoint pathways in effector T cells. In this review, we highlight recent advances in our understanding of how immunosuppression contributes to cancer and how proinflammatory mediators induce the immunosuppressive microenvironment via induction of immunosuppressive cells and activation of immune checkpoint pathways.

Original languageEnglish (US)
Pages (from-to)1085-1093
Number of pages9
JournalCarcinogenesis
Volume36
Issue number10
DOIs
StatePublished - Aug 16 2015

ASJC Scopus subject areas

  • Cancer Research

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