Abstract
The immune response to infection or disease can be very complex. The technique described would allow one to deconvolute the response and interret it. It should also be possible to use this method to discover immune reactive peptides or to infer what caused an immune response. This technique could be used as a standard diagnostic measure, to discover the cuase of infection or autoimmune disease, in a crisis situation to triage exposed people, to characterize the response to caccination as standard practice or in clinical trials. Existing approaches to broadly characterize an immune response involve multiple standard ELISAs, use of library panning involving multiple rounds of selection, or printing of known proteins from pathogens. These approaches apply to antibodies. T-cells and B-cells have also been characterized by isolating the recombination event. All of these processes are labor intensive and take time. They are not conductive to a startd clinical diagnostic protocol.
| Original language | English (US) |
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| State | Published - Jun 2 2006 |